L-Proline catalyzed domino Michael addition of N-substituted anilines

被引：16
|
作者：
Deb, Mohit L. [1 ]
Deka, Bhaskar [1 ]
Rahman, Iftakur [1 ]
Baruah, Pranjal K. [1 ]
机构：
[1] Gauhati Univ, GUIST, Dept Appl Sci, Gauhati 781014, Assam, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 50期
关键词：
N-substituted aniline; L-Proline; Michael addition; Domino reaction; Room temperature; MULTICOMPONENT SYNTHESIS; DRUG DISCOVERY; INDOLES; DERIVATIVES; CHEMISTRY; EFFICIENT; KETONES; KINASE;
D O I：
10.1016/j.tetlet.2018.11.004
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here we report L-proline catalyzed 3-component reaction of indoles, aldehydes and N-substituted anilines in water as solvent at room temperature for the synthesis of 3-(alpha,alpha-diarylmethyl)indoles. The reaction is in fact a Michael addition of N-substituted anilines to alkylideneindolenines. The reaction is very clean, high yielding and having broad substrate scope. A tentative mechanism is proposed. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4430 / 4433
页数：4
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