Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone

被引：154

作者：

Zhang, Y ^{[1
]}

Zhuo, RX ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Edu, Wuhan 430072, Peoples R China

来源：

BIOMATERIALS | 2005年 / 26卷 / 33期

基金：

中国国家自然科学基金;

关键词：

amphiphilic triblock copolymer; chain extender; poly (epsilon-caprolactone); poly (ethylene glycol); nanoparticle; drug release;

D O I：

10.1016/j.biomaterials.2005.03.045

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Novel BAB type amphiphilic triblock copolymers consisting of poly (ethylene glycol) (PFG) (B) as hydrophilic segment and poly (epsilon-caprolactone) (PCL) (A) as hydrophobic block were prepared by coupling reaction using t-lysine methyl ester diisocyanate (LDI) as the chain extender. The triblock copolymers obtained were characterized by FT-IR, H-1 NMR, GPC, and DSC. Core-shell type nanoparticles were prepared by nanoprecipitation method and below 100nm nanoparticles were obtained due to their specific structure. Transmission electron microscopy image demonstrated that these nanoparticles were spherical in shape, Stability of the nanoparticles in biological media was evaluated. Poorly water-soluble anticancer drug 4'-demethyl-epipodophyllotoxin (DMEP) was chosen for controlled drug release because it was easily encapsulated into polymeric nanoparticles via hydrophobic interaction. In vitro release behavior of DMEP from polymeric nanoparticles was investigated. the results showed that (lie drug release rate can be modulated by the variation of the copolymer composition, (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6736 / 6742

页数：7

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