Main Factors Involved in Thyroid Hormone Action

被引：19

作者：

Tedeschi, Lorena ^{[1
]}

Vassalle, Cristina ^{[2
]}

Iervasi, Giorgio ^{[1
]}

Sabatino, Laura ^{[1
]}

机构：

[1] CNR, Inst Clin Physiol, I-56127 Pisa, Italy

[2] Fdn CNR Reg Toscana Gabriele Monasterio, I-56127 Pisa, Italy

来源：

MOLECULES | 2021年 / 26卷 / 23期

关键词：

thyroid hormones; thyroid hormone receptor; integrin; genomic; nongenomic; ACTIVATED PROTEIN-KINASE; CELL-SURFACE RECEPTOR; TETRAIODOTHYROACETIC ACID; INTEGRIN ALPHA-V-BETA-3; MOLECULAR-BASIS; GROWTH-FACTOR; CANCER CELLS; L-THYROXINE; X-RECEPTOR; EXPRESSION;

D O I：

10.3390/molecules26237337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to genomic regulation, thyroid hormones function via activation of specific cytosolic pathways, bypassing interaction with nuclear DNA. In the present work, we reviewed the most recent literature on the characteristics and roles of different factors involved in thyroid hormone function in particular, we discuss the genomic activity of thyroid hormone receptors in the nucleus and the functions of different thyroid hormone receptor isoforms in the cytosol. Furthermore, we describe the integrin alpha v beta 3-mediated thyroid hormone signaling pathway and its rapid nongenomic action in the cell. We furthermore reviewed the thyroid hormone transporters enabling the uptake of thyroid hormones in the cell, and we also include a paragraph on the proteins that mediate thyroid receptors' shuttling from the nucleus to the cytosol.

引用

页数：9

共 63 条

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