Immunoglobulin G glycosylation in aging and diseases

被引：295

作者：

Gudelja, Ivan ^{[1
]}

Lame, Gordan ^{[1
,2
]}

Pezer, Marija ^{[1
]}

机构：

[1] Genos Glycosci Res Lab, Borongajska Cesta 83H, Zagreb 10000, Croatia

[2] Univ Zagreb, Fac Pharm & Biochem, Zagreb, Croatia

来源：

CELLULAR IMMUNOLOGY | 2018年 / 333卷

关键词：

IgG glycome; Aging; Disease; Biological age D; Differential glycosylation; Biomarker; FC N-GLYCOSYLATION; DEPENDENT CELLULAR CYTOTOXICITY; LINKED OLIGOSACCHARIDE CHAINS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INFLAMMATORY-BOWEL-DISEASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; CITRULLINATED PROTEIN ANTIBODIES; THERAPEUTIC IGG1 ANTIBODIES; SITE-SPECIFIC GLYCOSYLATION; ONSET RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.cellimm.2018.07.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations. IgG glycome composition is influenced both by genes and by environment, making it an excellent biomarker of a person's general health state, i.e. biological age. IgG glycosylation appears to be highly regulated, both during homeostasis and in cases of its disturbance. Changes in IgG glycosylation patterns have been observed in aging and in various diseases. Differential IgG glycosylation is known to modulate IgG effector functions and is involved in disease development and progression, representing both a predisposition and a functional mechanism involved in disease pathology. This makes IgG glycosylation analysis a promising add-on to improve existing disease biomarkers.

引用

页码：65 / 79

页数：15

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