Mathematical Modeling of Endemic Cholera Transmission

被引:1
作者
Chao, Dennis L. [1 ,2 ]
机构
[1] Inst Dis Modeling, Seattle, WA USA
[2] Bill & Melinda Gates Fdn, Seattle, WA 98109 USA
关键词
Cholera; mathematical modeling; oral cholera vaccine; VACCINATION STRATEGIES; SEASONAL INFLUENZA; HERD-IMMUNITY; BANGLADESH; EPIDEMIC; VACCINES; MEASLES; HAITI; RISK;
D O I
10.1093/infdis/jiab472
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mathematical modeling can be used to project the impact of mass vaccination on cholera transmission. Here, we discuss 2 examples for which indirect protection from mass vaccination needs to be considered. In the first, we show that nonvaccinees can be protected by mass vaccination campaigns. This additional benefit of indirect protection improves the cost-effectiveness of mass vaccination. In the second, we model the use of mass vaccination to eliminate cholera. In this case, a high population level of immunity, including contributions from infection and vaccination, is required to reach the "herd immunity" threshold needed to stop transmission and achieve elimination.
引用
收藏
页码:S738 / S741
页数:4
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