Current status of uterine regenerative medicine for absolute uterine factor infertility

被引:5
作者
Matoba, Yusuke [1 ]
Kisu, Iori [1 ]
Sera, Asako [1 ]
Yanokura, Megumi [1 ]
Banno, Kouji [1 ]
Aoki, Daisuke [1 ]
机构
[1] Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1608582, Japan
基金
日本学术振兴会;
关键词
absolute uterine factor infertility; bioengineering; uterine regeneration; tissue engineering; Mayer-Rokitansky-Kuster-Hauser syndrome; MESENCHYMAL STEM-CELLS; ENDOMETRIAL REGENERATION; UTERUS TRANSPLANTATION; CLINICAL-APPLICATION; COLLAGEN SCAFFOLDS; RAT UTERUS; THICKNESS; GROWTH; RECELLULARIZATION; MODEL;
D O I
10.3892/br.2019.1182
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myometrium in vivo. In the present report, those relevant articles are reviewed. A literature search was conducted in PubMed with a combination of key words, and 10 articles were found, including nine in rat models and one in a mouse model. Of these studies, eight used scaffolds and two were performed without scaffolds. In four of these studies, scaffolds were re-cellularized with various cells. In the remaining four studies, scaffolds were transplanted alone, or other structures were used. Though the methods differed, the injured uterus recovered well, morphologically and functionally, in every study. Only 10 articles were relevant to our investigation, but the results were favorable, if limited to partial regeneration. Recently, uterus transplantation (UTx) has been investigated as a treatment for AUFI. However, UTx has many problems in the medical, ethical and social fields. Though the artificial uterus was also researched and some improvements in this technology were reported, it will take long time for this to reach a clinically applicable stage. Though the results of uterine regeneration studies were promising, these studies were conducted using animal models, so further human studies and trials are needed.
引用
收藏
页码:79 / 86
页数:8
相关论文
共 45 条
[1]   Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome [J].
Alawadhi, Feryal ;
Du, Hongling ;
Cakmak, Hakan ;
Taylor, Hugh S. .
PLOS ONE, 2014, 9 (05)
[2]   Livebirth after uterus transplantation [J].
Brannstrom, Mats ;
Johannesson, Liza ;
Bokstrom, Hans ;
Kvarnstrom, Niclas ;
Molne, Johan ;
Dahm-Kahler, Pernilla ;
Enskog, Anders ;
Milenkovic, Milan ;
Ekberg, Jana ;
Diaz-Garcia, Cesar ;
Gabel, Markus ;
Hanafy, Ash ;
Hagberg, Henrik ;
Olausson, Michael ;
Nilsson, Lars .
LANCET, 2015, 385 (9968) :607-616
[3]   First clinical uterus transplantation trial: a six-month report [J].
Brannstrom, Mats ;
Johannesson, Liza ;
Dahm-Kahler, Pernilla ;
Enskog, Anders ;
Molne, Johan ;
Kvarnstrom, Niclas ;
Diaz-Garcia, Cesar ;
Hanafy, Ash ;
Lundmark, Cecilia ;
Marcickiewicz, Janusz ;
Gabel, Markus ;
Groth, Klaus ;
Akouri, Randa ;
Eklind, Saskia ;
Holgersson, Jan ;
Tzakis, Andreas ;
Olausson, Michael .
FERTILITY AND STERILITY, 2014, 101 (05) :1228-1236
[4]   The peritoneal cavity as a bioreactor for tissue engineering visceral organs: bladder, uterus and vas deferens [J].
Campbell, Gordon R. ;
Turnbull, Geoffrey ;
Xiang, Lina ;
Haines, Michael ;
Armstrong, Shannon ;
Rolfe, Barbara E. ;
Campbell, Julie H. .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 2 (01) :50-60
[5]   Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome [J].
Cervello, Irene ;
Gil-Sanchis, Claudia ;
Santamaria, Xavier ;
Cabanillas, Sergio ;
Diaz, Ana ;
Faus, Amparo ;
Pellicer, Antonio ;
Simon, Carlos .
FERTILITY AND STERILITY, 2015, 104 (06) :1552-+
[6]   TISSUE ENGINEERING BY CELL TRANSPLANTATION USING DEGRADABLE POLYMER SUBSTRATES [J].
CIMA, LG ;
VACANTI, JP ;
VACANTI, C ;
INGBER, D ;
MOONEY, D ;
LANGER, R .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1991, 113 (02) :143-151
[7]   Challenges in vascular tissue engineering for diabetic patients [J].
Dhulekar, Jhilmil ;
Simionescu, Agneta .
ACTA BIOMATERIALIA, 2018, 70 :25-34
[8]   Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus [J].
Ding, Lijun ;
Li, Xin'an ;
Sun, Haixiang ;
Su, Jing ;
Lin, Nacheng ;
Peault, Bruno ;
Song, Tianran ;
Yang, Jun ;
Dai, Jianwu ;
Hu, Yali .
BIOMATERIALS, 2014, 35 (18) :4888-4900
[9]   Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions [J].
Gan, Lu ;
Duan, Hua ;
Xu, Qian ;
Tang, Yi-Qun ;
Li, Jin-Jiao ;
Sun, Fu-Qing ;
Wang, Sha .
CYTOTHERAPY, 2017, 19 (05) :603-616
[10]   3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo [J].
Gholipourmalekabadi, Mazaher ;
Seifalian, Alexander M. ;
Urbanska, Aleksandra M. ;
Omrani, Mir Davood ;
Hardy, John G. ;
Madjd, Zahra ;
Hashemi, Seyed Mahmoud ;
Ghanbarian, Hossein ;
Milan, Peiman Brouki ;
Mozafari, Masoud ;
Reis, Rui L. ;
Kundu, Subhas C. ;
Samadikuchaksaraei, Ali .
BIOMACROMOLECULES, 2018, 19 (07) :2409-2422