Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities

被引：66
作者：
Pircher, Andreas [1 ,2 ]
Treps, Lucas [1 ,2 ]
Bodrug, Natalia [1 ,2 ,3 ]
Carmeliet, Peter [1 ,2 ]
机构：
[1] Katholieke Univ Leuven, Dept Oncol, Lab Angiogenesis & Vasc Metab, B-3000 Leuven, Belgium
[2] VIB, Vesalius Res Ctr, Lab Angiogenesis & Vasc Metab, B-3000 Leuven, Belgium
[3] Queen Mary Univ London, John Vane Sci Ctr, Lab Adhes & Angiogenesis, Ctr Tumour Biol,Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England
来源：
ATHEROSCLEROSIS | 2016年 / 253卷
基金：
奥地利科学基金会; 欧洲研究理事会;
关键词：
Atherosclerosis; Endothelial cell; Endothelial cell metabolism; Glycolysis; Angiogenesis; NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; P-CRESYL SULFATE; PENTOSE-PHOSPHATE PATHWAY; OXIDATIVE STRESS; HYDROGEN-SULFIDE; INDOXYL SULFATE; NADPH OXIDASES; UP-REGULATION;
D O I：
10.1016/j.atherosclerosis.2016.08.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite improved insight into disease pathogenesis and therapeutic options, additional treatment strategies are required. Emerging evidence highlights the relevance of endothelial cell (EC) metabolism for angiogenesis, and indicates that EC metabolism is perturbed when ECs become dysfunctional to promote atherogenesis. In this review, we overview the latest insights on EC metabolism and discuss current knowledge on how atherosclerosis deregulates EC metabolism, and how maladaptation of deregulated EC metabolism can contribute to atherosclerosis progression. We will also highlight possible therapeutic avenues, based on targeting EC metabolism. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：247 / 257
页数：11
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