Brain MRI abnormalities in ataxia-telangiectasia

被引：19

作者：

Habek, Mario ^{[1
,2
]}

Brinar, Vesna V. ^{[1
,2
]}

Rados, Marko ^{[3
]}

Zadro, Ivana ^{[1
,2
]}

Zarkovic, Kamelija ^{[4
,5
]}

机构：

[1] Univ Zagreb, Ctr Hosp, Univ Dept Neurol, HR-10000 Zagreb, Croatia

[2] Zagreb Sch Med, Univ Dept Neurol, Referral Ctr Demyelinating Dis Cent Nervous Syst, Zagreb, Croatia

[3] Zagreb Sch Med, Dept Radiol, Zagreb, Croatia

[4] Zagreb Sch Med, Dept Pathol, Zagreb, Croatia

[5] Univ Hosp Ctr, Zagreb, Croatia

来源：

NEUROLOGIST | 2008年 / 14卷 / 03期

关键词：

ataxia-telangiectasia; magnetic resonance imaging; demyelination; age;

D O I：

10.1097/NRL.0b013e31815fa5a7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder. initially characterized by normal brain magnetic resonance imaging (MRI). Case report: In a 34-year-old woman patient with AT, MRI revealed extensive and diffuse white matter dismyelination, T1 and T2 hypointense lesions, T1 hypointense but T2 hyperintense lesions, and numerous dilated telangiectases upon gadolinium enhancement. Discussion: In our patient, brain MRI confirmed extensive extracerebellar lesions in AT. Conclusion: Our report broadens the spectrum of brain MRI abnormalities in AT and supports the hypothesis on cerebrovascular abnormalities occurring in later stages of AT.

引用

页码：192 / 195

页数：4

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