New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum

被引：38

作者：

Jang, Kyoung Hwa ^{[1
]}

Chang, Yong Ha ^{[1
]}

Kim, Dae-Duk ^{[1
]}

Oh, Ki-Bong ^{[2
]}

Oh, Uhtaek ^{[3
]}

Shin, Jongheon ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea

[2] Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151921, South Korea

[3] Seoul Natl Univ, Coll Pharm, CRI, Sensory Res Ctr, Seoul 151742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 05期

关键词：

Zanthoxylum piperitum; fatty acid amides; sanshools; dihydroxy-alpha-sanshool; dihydroxy-beta-sanshool; cytotoxicity;

D O I：

10.1007/s12272-001-1194-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five linear fatty acid amides (1-5) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2',3'-dihydroxy-alpha-sanshool and 2',3'-dihydroxy-beta-sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.

引用

页码：569 / 572

页数：4

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