200th anniversary of lactate research in muscle

被引：33

作者：

Gladden, L. Bruce ^{[1
]}

机构：

[1] Auburn Univ, Dept Kinesiol, Auburn, AL 36849 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2008年 / 36卷 / 03期

关键词：

intracellular lactate shuttle; lactate dehydrogenase; lactic dehydrogenase; isozymes; history;

D O I：

10.1097/JES.0b013e31817c0038

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This year, 2008, marks the bicentennial of research into lactate metabolism in muscle. Berzelius linked lactate accumulation to exercise in 1807/1808 when he noted the presence of lactate in the muscles of "hunted stags." Today, the exact mechanism of intramuscular lactate oxidation and the relationship of lactate dehydrogenase to mitochondria remain unresolved as animated debate surrounds the intracellular lactate shuttle.

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页码：109 / 115

页数：7

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