Diffusion tensor imaging of the hippocampus and verbal memory performance: The RUN DMC Study

被引：44

作者：

van Norden, Anouk G. W. ^{[1
]}

de Laat, Karlijn F. ^{[1
]}

Fick, Ilma ^{[1
]}

van Uden, Ingew. M. ^{[1
]}

van Oudheusden, Lucas J. B. ^{[1
]}

Gons, Rob A. R. ^{[1
]}

Norris, David G. ^{[2
]}

Zwiers, Marcel P. ^{[2
,3
]}

Kessels, Roy P. C. ^{[2
,4
,5
,6
]}

de Leeuw, Frank-Erik ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Ctr Neurosci,Dept Neurol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, NL-6500 HE Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Dept Psychiat, Donders Inst Brain Cognit & Behav, Ctr Neurosci,Dept Neurol, NL-6500 HB Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Ctr Cognit, Donders Inst Brain Cognit & Behav, NL-6500 HE Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, NL-6500 HB Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Geriatr, NL-6500 HB Nijmegen, Netherlands

来源：

HUMAN BRAIN MAPPING | 2012年 / 33卷 / 03期

关键词：

cognition; memory; dementia; elderly; cerebral small vessel disease; hippocampus; imaging; magnetic resonance imaging; diffusion tensor imaging; MILD COGNITIVE IMPAIRMENT; WHITE-MATTER LESIONS; MEDIAL TEMPORAL-LOBE; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; LEARNING TEST; DIAGNOSTIC-CRITERIA; ROTTERDAM SCAN; MRI; BRAIN;

D O I：

10.1002/hbm.21231

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Cerebral small vessel disease (SVD) and hippocampal atrophy are related to verbal memory failures and may ultimately result in Alzheimer's disease. However, verbal memory failures are often present before structural changes on conventional MRI appear. Changes in microstructural integrity of the hippocampus, which cannot be detected with conventional MRI, may be the underlying pathological substrate. With diffusion tensor imaging (DTI), we investigated the relation between the microstructural integrity of the hippocampus and verbal memory performance in 503 nondemented elderly with SVD. Methods: The Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort study is a prospective cohort study among 503 nondemented elderly with cerebral SVD aged between 50 and 85 years. All participants underwent T1 MPRAGE, fluid-attenuated inversion recovery, DTI scanning and the Rey Auditory Verbal Learning Test. After manual segmentation of the hippocampi, we calculated the mean diffusivity (MD) and fractional anisotropy in both hippocampi. The relation between memory performance and hippocampal DTI parameters was adjusted for age, sex, education, depressive symptoms, hippocampal, and white-matter lesions volume and lacunar infarcts. Results: We found inverse relations between hippocampal MD and verbal memory performance (beta = -0.22; P < 0.001), immediate recall (beta = -0.22; P < 0.001), delayed recall (beta = -0.20; P < 0.001), and forgetting rate (beta = -0.13; P = 0.025), most pronounced in participants with a normal hippocampal volume. Conclusion: Microstructural integrity of the hippocampus assessed by DTI is related to verbal memory performance in elderly with SVD, also in participants with an intact appearing hippocampus. Changes in hippocampal microstructure may be an early marker of underlying neurodegenerative disease, before macrostructural (i.e., volumetric) changes occur. Hum Brain Mapp, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：542 / 551

页数：10

共 51 条

[41] Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding [J].