Searching for autoimmune encephalitis: Beware of normal CSF

被引:35
作者
Hebert, Julien [1 ]
Gros, Priti [1 ]
Lapointe, Sarah [1 ,2 ]
Amtashar, Fatima S. [3 ]
Steriade, Claude [4 ]
Maurice, Catherine [1 ,2 ]
Wennberg, Richard A. [1 ,2 ]
Day, Gregory S. [5 ]
Tang-Wai, David F. [1 ,2 ]
机构
[1] Univ Toronto, Div Neurol, Toronto, ON, Canada
[2] Univ Hlth Network, Toronto, ON, Canada
[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[4] NYU, Langone Comprehens Epilepsy Ctr, New York, NY USA
[5] Mayo Clin Florida, Dept Neurol, Jacksonville, FL USA
基金
美国国家卫生研究院;
关键词
Autoimmune encephalitis; Autoimmune diseases; Encephalitis; Diagnostic studies; Cerebrospinal fluid; NMDA-RECEPTOR ENCEPHALITIS; FACIOBRACHIAL DYSTONIC SEIZURES; LIMBIC ENCEPHALITIS; COGNITIVE DEFICITS; LEUCINE-RICH; CASE SERIES; ANTIBODIES; OUTCOMES; PROTEIN;
D O I
10.1016/j.jneuroim.2020.577285
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To determine the prevalence of cerebrospinal fluid (CSF) markers associated with inflammation (i.e., elevated white blood cell count, protein concentration, and CSF-specific oligoclonal bands) in patients with early active autoimmune encephalitis (AE). Methods: CSF characteristics, including WBC count, protein concentration, and oligoclonal banding, were analyzed in patients diagnosed with AE at two tertiary care centers. Results: Ninety-five patients were included in the study. CSF white blood cell counts and protein levels were within normal limits for 27% (CI95%: 19-37) of patients with AE. When results of oligoclonal banding were added, 14% (CI95%: 6-16) of patients with AE had "normal" CSF. The median CSF white blood cell count was 8 cells/mm(3) (range: 0-544) and the median CSF protein concentration was 0.42 g/L (range: 0.15-3.92). Conclusions: White blood cell counts and protein levels were within normal limits in the CSF of a substantial proportion of patients with early active AE. Inclusion of CSF oligoclonal banding identified a higher proportion of patients with an inflammatory CSF profile, especially when CSF was sampled early in the disease process.
引用
收藏
页数:8
相关论文
共 28 条
[1]   A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis [J].
Balu, Ramani ;
McCracken, Lindsey ;
Lancaster, Eric ;
Graus, Francesc ;
Dalmau, Josep ;
Titulaer, Maarten J. .
NEUROLOGY, 2019, 92 (03) :E244-E252
[2]   Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis [J].
Blinder, Tetyana ;
Lewerenz, Jan .
FRONTIERS IN NEUROLOGY, 2019, 10
[3]   An Overview of Autoimmune and Paraneoplastic Encephalitides [J].
Bradshaw, Michael J. ;
Linnoila, Jenny J. .
SEMINARS IN NEUROLOGY, 2018, 38 (03) :330-343
[4]   Updated cerebrospinal fluid total protein reference values improve chronic inflammatory demyelinating polyneuropathy diagnosis [J].
Breiner, Ari ;
Bourque, Pierre R. ;
Allen, Jeffrey A. .
MUSCLE & NERVE, 2019, 60 (02) :180-183
[5]   Testing for N-methyl-d-aspartate Receptor Autoantibodies in Clinical Practice [J].
Brooks, John ;
Yarbrough, Melanie L. ;
Bucelli, Robert C. ;
Day, Gregory S. .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2020, 47 (01) :69-76
[6]   Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies [J].
Dalmau, Josep ;
Gleichman, Amy J. ;
Hughes, Ethen G. ;
Rossi, Jeffrey E. ;
Peng, Xiaoyu ;
Lai, Meizan ;
Dessain, Scott K. ;
Rosenfeld, Mynna R. ;
Balice-Gordon, Rita ;
Lynch, David R. .
LANCET NEUROLOGY, 2008, 7 (12) :1091-1098
[7]   Autoimmune Encephalitis Epidemiology and a Comparison to Infectious Encephalitis [J].
Dubey, Divyanshu ;
Pittock, Sean J. ;
Kelly, Cecilia R. ;
McKeon, Andrew ;
Lopez-Chiriboga, Alfonso Sebastian ;
Lennon, Vanda A. ;
Gadoth, Avi ;
Smith, Carin Y. ;
Bryant, Sandra C. ;
Klein, Christopher J. ;
Aksamit, Allen J. ;
Toledano, Michel ;
Boeve, Bradley F. ;
Tillema, Jan-Mendelt ;
Flanagan, Eoin P. .
ANNALS OF NEUROLOGY, 2018, 83 (01) :166-177
[8]   Antibody-associated CNS syndromes without signs of inflammation in the elderly [J].
Escudero, Domingo ;
Guasp, Mar ;
Arino, Helena ;
Gaig, Carles ;
Martinez-Hernandez, Eugenia ;
Dalmau, Josep ;
Graus, Francesc .
NEUROLOGY, 2017, 89 (14) :1471-1475
[9]   Evaluation of Cognitive Deficits and Structural Hippocampal Damage in Encephalitis With Leucine-Rich, Glioma-Inactivated 1 Antibodies [J].
Finke, Carsten ;
Pruess, Harald ;
Heine, Josephine ;
Reuter, Sigrid ;
Kopp, Ute A. ;
Wegner, Florian ;
Bergh, Florian Then ;
Koch, Sebastian ;
Jansen, Olav ;
Muente, Thomas ;
Deuschl, Guenther ;
Ruprecht, Klemens ;
Stoecker, Winfried ;
Wandinger, Klaus-Peter ;
Paul, Friedemann ;
Bartsch, Thorsten .
JAMA NEUROLOGY, 2017, 74 (01) :50-59
[10]   Cognitive deficits following anti-NMDA receptor encephalitis [J].
Finke, Carsten ;
Kopp, Ute A. ;
Pruess, Harald ;
Dalmau, Josep ;
Wandinger, Klaus-Peter ;
Ploner, Christoph J. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2012, 83 (02) :195-198