Novel insights into the interaction between N6-methyladenosine modification and circular RNA

被引：32

作者：

Xu, Tao ^{[1
]}

He, Bangshun ^{[2
]}

Sun, Huiling ^{[1
]}

Xiong, Mengqiu ^{[1
]}

Nie, Junjie ^{[1
]}

Wang, Shukui ^{[1
]}

Pan, Yuqin ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Gen Clin Res Ctr, Nanjing 210006, Peoples R China

[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Lab Med, Nanjing 210006, Peoples R China

来源：

MOLECULAR THERAPY NUCLEIC ACIDS | 2022年 / 27卷

基金：

中国国家自然科学基金;

关键词：

MESSENGER-RNA; NUCLEAR-RNA; CELL-PROLIFERATION; BINDING-PROTEIN; CANCER; N-6-METHYLADENOSINE; METHYLATION; TRANSLATION; BIOGENESIS; GENE;

D O I：

10.1016/j.omtn.2022.01.007

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. In this review, we summarize the characteristics and biological functions of m(6)A and circRNAs and focus on recent advances in the interaction of m(6)A modification and circRNAs. In addition, the potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are discussed.

引用

页码：824 / 837

页数：14

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