Organoids, Where We Stand and Where We Go

被引:20
作者
Don, Flaminia Kaluthantrige [1 ,2 ,3 ]
Huch, Meritxell [1 ]
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England
[3] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England
基金
英国生物技术与生命科学研究理事会;
关键词
STEM-CELLS;
D O I
10.1016/j.molmed.2021.03.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Organoid cultures hold the promise of transforming basic and clinical research. Here, we provide a storyline of the highlights and breakthroughs that have an impact in present clinical research. We also discuss the bottlenecks that delay their full exploitation for the next generation of biomedical research.
引用
收藏
页码:416 / 418
页数:3
相关论文
共 12 条
[1]   Generation of Functional Human 3D Cortico-Motor Assembloids [J].
Andersen, Jimena ;
Revah, Omer ;
Miura, Yuki ;
Thom, Nicholas ;
Amin, Neal D. ;
Kelley, Kevin W. ;
Singh, Mandeep ;
Chen, Xiaoyu ;
Thete, Mayuri Vijay ;
Walczak, Elisabeth M. ;
Vogel, Hannes ;
Fan, H. Christina ;
Pasca, Sergiu P. .
CELL, 2020, 183 (07) :1913-+
[2]   Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis [J].
Berkers, Gitte ;
van Mourik, Peter ;
Vonk, Annelotte M. ;
Kruisselbrink, Evelien ;
Dekkers, Johanna F. ;
de Winter-de Groot, Karin M. ;
Arets, Hubertus G. M. ;
Marck-van der Wilt, Rozemarijn E. P. ;
Dijkema, Jasper S. ;
Vanderschuren, Maaike M. ;
Houwen, Roderick H. J. ;
Heijerman, Harry G. M. ;
van de Graaf, Eduard A. ;
Elias, Sjoerd G. ;
Majoor, Christof J. ;
Koppelman, Gerard H. ;
Roukema, Jolt ;
Bakker, Marleen ;
Janssens, Hettie M. ;
van der Meer, Renske ;
Vries, Robert G. J. ;
Clevers, Hans C. ;
de Jonge, Hugo R. ;
Beekman, Jeffrey M. ;
van der Ent, Cornelis K. .
CELL REPORTS, 2019, 26 (07) :1701-+
[3]   Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals [J].
Eiraku, Mototsugu ;
Watanabe, Kiichi ;
Matsuo-Takasaki, Marni ;
Kawada, Masako ;
Yonemura, Shigenobu ;
Matsumura, Michiru ;
Wataya, Takafumi ;
Nishiyama, Ayaka ;
Muguruma, Keiko ;
Sasail, Yoshiki .
CELL STEM CELL, 2008, 3 (05) :519-532
[4]   Zika virus impairs growth in human neurospheres and brain organoids [J].
Garcez, Patricia P. ;
Loiola, Erick Correia ;
da Costa, Rodrigo Madeiro ;
Higa, Luiza M. ;
Trindade, Pablo ;
Delvecchio, Rodrigo ;
Nascimento, Juliana Minardi ;
Brindeiro, Rodrigo ;
Tanuri, Amilcar ;
Rehen, Stevens K. .
SCIENCE, 2016, 352 (6287) :816-818
[5]   Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver [J].
Huch, Meritxell ;
Gehart, Helmuth ;
van Boxtel, Ruben ;
Hamer, Karien ;
Blokzijl, Francis ;
Verstegen, Monique M. A. ;
Ellis, Ewa ;
van Wenum, Martien ;
Fuchs, Sabine A. ;
de Ligt, Joep ;
van de Wetering, Marc ;
Sasaki, Nobuo ;
Boers, Susanne J. ;
Kemperman, Hans ;
de Jonge, Jeroen ;
Ijzermans, Jan N. M. ;
Nieuwenhuis, Edward E. S. ;
Hoekstra, Ruurdtje ;
Strom, Stephen ;
Vries, Robert R. G. ;
van der Laan, Luc J. W. ;
Cuppen, Edwin ;
Clevers, Hans .
CELL, 2015, 160 (1-2) :299-312
[6]   Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary [J].
Koike, Hiroyuki ;
Iwasawa, Kentaro ;
Ouchi, Rie ;
Maezawa, Mari ;
Giesbrecht, Kirsten ;
Saiki, Norikazu ;
Ferguson, Autumn ;
Kimura, Masaki ;
Thompson, Wendy L. ;
Wells, James M. ;
Zorn, Aaron M. ;
Takebe, Takanori .
NATURE, 2019, 574 (7776) :112-+
[7]   Cerebral organoids model human brain development and microcephaly [J].
Lancaster, Madeline A. ;
Renner, Magdalena ;
Martin, Carol-Anne ;
Wenzel, Daniel ;
Bicknell, Louise S. ;
Hurles, Matthew E. ;
Homfray, Tessa ;
Penninger, Josef M. ;
Jackson, Andrew P. ;
Knoblich, Juergen A. .
NATURE, 2013, 501 (7467) :373-+
[8]   Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation [J].
Lawlor, Kynan T. ;
Vanslambrouck, Jessica M. ;
Higgins, J. William ;
Chambon, Alison ;
Bishard, Kristina ;
Arndt, Derek ;
Er, Pei Xuan ;
Wilson, Sean B. ;
Howden, Sara E. ;
Tan, Ker Sin ;
Li, Fanyi ;
Hale, Lorna J. ;
Shepherd, Benjamin ;
Pentoney, Stephen ;
Presnell, Sharon C. ;
Chen, Alice E. ;
Little, Melissa H. .
NATURE MATERIALS, 2021, 20 (02) :260-+
[9]   Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 [J].
Monteil, Vanessa ;
Kwon, Hyesoo ;
Prado, Patricia ;
Hagelkruys, Astrid ;
Wimmer, Reiner A. ;
Stahl, Martin ;
Leopoldi, Alexandra ;
Garreta, Elena ;
del Pozo, Carmen Hurtado ;
Prosper, Felipe ;
Romero, Juan Pablo ;
Wirnsberger, Gerald ;
Zhang, Haibo ;
Slutsky, Arthur S. ;
Conder, Ryan ;
Montserrat, Nuria ;
Mirazimi, Ali ;
Penninger, Josef M. .
CELL, 2020, 181 (04) :905-+
[10]   Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche [J].
Sato, Toshiro ;
Vries, Robert G. ;
Snippert, Hugo J. ;
van de Wetering, Marc ;
Barker, Nick ;
Stange, Daniel E. ;
van Es, Johan H. ;
Abo, Arie ;
Kujala, Pekka ;
Peters, Peter J. ;
Clevers, Hans .
NATURE, 2009, 459 (7244) :262-U147