Molecular and Immune Biomarkers in Acute Respiratory Distress Syndrome A Perspective From Members of the Pulmonary Pathology Society

被引：35

作者：

Capelozzi, Vera Luiza ^{[1
]}

Allen, Timothy Craig ^{[2
]}

Beasley, Mary Beth ^{[3
]}

Cagle, Philip T. ^{[4
]}

Guinee, Don ^{[5
]}

Hariri, Lida P. ^{[6
]}

Husain, Aliya N. ^{[7
]}

Jain, Deepali ^{[8
]}

Lantuejoul, Sylvie ^{[9
,10
]}

Larsen, Brandon T. ^{[11
]}

Miller, Ross ^{[4
]}

Mino-Kenudson, Mari ^{[6
]}

Mehrad, Mitra ^{[12
]}

Raparia, Kirtee ^{[13
]}

Roden, Anja ^{[14
]}

Schneider, Frank ^{[15
]}

Sholl, Lynette M. ^{[16
]}

Smith, Maxwell Lawrence ^{[11
]}

机构：

[1] Univ Sao Paulo, Dept Pathol, Sao Paulo, Brazil

[2] Univ Texas Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 USA

[3] Mt Sinai Med Ctr, Dept Pathol, New York, NY 10029 USA

[4] Houston Methodist Hosp, Dept Pathol & Genom Med, Houston, TX USA

[5] Virginia Mason Med Ctr, Dept Pathol, Seattle, WA 98101 USA

[6] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[7] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[8] All India Inst Med Sci, Dept Pathol, New Delhi, India

[9] Ctr Leon Berard, INSERM Unit, Dept Pathol, Lyon, France

[10] Univ Joseph Fourier, INSERM Unit, Grenoble, France

[11] Mayo Clin, Dept Lab Med & Pathol, Scottsdale, AZ USA

[12] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA

[13] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[14] Mayo Clin Rochester, Dept Lab Med & Pathol, Rochester, MN USA

[15] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[16] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2017年 / 141卷 / 12期

基金：

巴西圣保罗研究基金会;

关键词：

ACUTE LUNG INJURY; BRONCHOALVEOLAR LAVAGE FLUID; GLYCATION END-PRODUCTS; VON-WILLEBRAND-FACTOR; C-REACTIVE PROTEIN; EDEMA FLUID; MATRIX METALLOPROTEINASES; TISSUE FACTOR; PLASMA; MORTALITY;

D O I：

10.5858/arpa.2017-0115-SA

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Acute respiratory distress syndrome (ARDS) is a multifactorial syndrome with high morbidity and mortality rates, characterized by deficiency in gas exchange and lung mechanics that lead to hypoxemia, dyspnea, and respiratory failure. Histologically, ARDS is characterized by an acute, exudative phase, combining diffuse alveolar damage and noncardiogenic edema, followed by a later fibroproliferative phase. Despite an enhanced understanding of ARDS pathogenesis, the capacity to predict the development of ARDS and to risk-stratify patients with the disease remains limited. Biomarkers may help to identify patients at the greatest risk of developing ARDS, to evaluate response to therapy, to predict outcome, and to improve clinical trials. The ARDS pathogenesis is presented in this article, as well as concepts and information on biomarkers that are currently used clinically or are available for laboratory use by academic and practicing pathologists and the developing and validating of new assays, focusing on the assays' major biologic roles in lung injury and/or repair and to ultimately suggest innovative, therapeutic approaches.

引用

页码：1719 / 1727

页数：9

共 71 条

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