The 'invisible hand': regulation of RHO GTPases by RHOGDIs

被引：389
作者：
Garcia-Mata, Rafael [1 ]
Boulter, Etienne [2 ]
Burridge, Keith [1 ,3 ,4 ]
机构：
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Nice Sophia Antipolis Univ, Inst Natl St & Rech Med, U634, Avenir Team, F-06107 Nice, France
[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, McAllister Heart Inst, Chapel Hill, NC 27599 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 08期
基金：
美国国家卫生研究院;
关键词：
GDP-DISSOCIATION-INHIBITOR; GTP-BINDING PROTEIN; TYROSINE KINASE; CELL-MIGRATION; PERINEURAL INVASION; PROTEOMIC ANALYSIS; TUMOR PROGRESSION; ACTIVATING MUTANT; CRYSTAL-STRUCTURE; BARRIER FUNCTION;
D O I：
10.1038/nrm3153
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.
引用
收藏
页码：493 / 504
页数：12
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