Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14

被引：45

作者：

Bringmann, G

Lang, G

Maksimenka, K

Hamm, A

Gulder, TAM

Dieter, A

Bull, AT

Stach, JEM

Kocher, N

Müller, WEG

Fiedler, HP

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[3] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England

[4] Univ Newcastle, Inst Res Environm & Sustainabil, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Wurzburg, Inst Anorgan Chem, D-97074 Wurzburg, Germany

[6] Univ Mainz, Inst Physiol Chem, Abt Angew Mol Biol, D-55099 Mainz, Germany

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 11期

关键词：

Streptomyces; angucyclinones; natural products; secondary metabolites; glutaminergic activity; circular dichroism (CD); quantum chemical CD calculations; X-ray structure analysis;

D O I：

10.1016/j.phytochem.2005.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1366 / 1373

页数：8

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