Impact of C-reactive protein and albumin levels on short, medium, and long term mortality in patients with diffuse large B-cell lymphoma

被引:12
作者
Gradel, Kim Oren [1 ,2 ,3 ]
Larsen, Thomas Stauffer [4 ,5 ]
Frederiksen, Henrik [4 ,5 ]
Vinholt, Pernille Just [6 ]
Iachina, Maria [1 ,2 ]
Povoa, Pedro [1 ,2 ,7 ,8 ]
Zampieri, Fernando Godinho [1 ,2 ,9 ]
Nielsen, Stig Lonberg [10 ,11 ]
Dessau, Ram Benny [12 ]
Moller, Jens Kjolseth [13 ]
Jensen, Thoger Gorm [14 ,15 ]
Chen, Ming [16 ]
Coia, John Eugenio [17 ]
Jelicic, Jelena [4 ,5 ]
机构
[1] Univ Southern Denmark, Odense Univ Hosp, Ctr Clin Epidemiol, Odense C, Denmark
[2] Univ Southern Denmark, Res Unit Clin Epidemiol, Dept Clin Res, Odense C, Denmark
[3] Odense Univ Hosp, OPEN Odense Patient Data Exploratory Network, Odense C, Denmark
[4] Univ Southern Denmark, Odense Univ Hosp, Dept Haematol, Odense C, Denmark
[5] Univ Southern Denmark, Res Unit Haematol, Dept Clin Res, Odense C, Denmark
[6] Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense C, Denmark
[7] CHLO, Hosp Sao Francisco Xavier, Polyvalent Intens Care Unit, Estr Forte Alto Duque, Lisbon, Portugal
[8] Univ Nova Lisboa, NOVA Med Sch, CEDOC, Lisbon, Portugal
[9] dHCor Hosp Coracao, Res Inst, Sao Paulo, Brazil
[10] Univ Southern Denmark, Odense Univ Hosp, Dept Infect Dis, Odense, Denmark
[11] Univ Southern Denmark, Res Unit Infect Dis, Dept Clin Res, Odense, Denmark
[12] Slagelse Hosp, Dept Clin Microbiol, Slagelse, Denmark
[13] Univ Hosp Southern Denmark, Vejle Hosp, Dept Clin Microbiol, Vejle, Denmark
[14] Univ Southern Denmark, Odense Univ Hosp, Dept Clin Microbiol, Odense C, Denmark
[15] Univ Southern Denmark, Dept Clin Res, Res Unit Clin Microbiol, Odense C, Denmark
[16] Hosp Southern Jutland, Dept Clin Microbiol, Sonderborg, Denmark
[17] Hosp South West Jutland, Dept Clin Microbiol, Esbjerg, Denmark
关键词
Diffuse large B-cell lymphoma; prognosis; C-reactive protein; plasma albumin; inflammation; PROGNOSTIC INDEX; ELDERLY-PATIENTS; NCCN-IPI; R-CHOP; SURVIVAL; SYSTEM; SCORE; BACTEREMIA; PREDICTOR; DIAGNOSIS;
D O I
10.1080/07853890.2022.2046287
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives and study design: In this population-based study of 602 patients, we amended C-reactive protein (CRP) and plasma albumin (PA) levels around the diagnosis of diffuse large B-cell lymphoma (DLBCL) to the International Prognostic Index (IPI) and assessed 0-90, 91-365, and +365-day survival. Results: The CRP did not contribute to the IPI's prognostic or discriminatory ability, regardless of time period, particularly not in models with PA. In contrast, the PA was an important contributor, especially in the 0-90 day period, but also up to one year after the diagnosis. For day 0-90, the model with the IPI only had an Area Under the Receiver Operating Characteristics (AUROC) of 0.742, whereas the IPI with PA as a continuous variable rendered an AUROC of 0.841. Especially the lower PA quartile (18-32 g/L) contributed to the worse prognosis. Conclusions: The amendment of PA to the IPI may significantly improve the short-term prognostic and discriminative ability. Key messages The amendment of the plasma albumin (PA) level to the International Prognostic Index significantly improved the prediction of mortality up to one year after the diagnosis of diffuse large B-cell lymphoma. It was especially the lower quartile of the PA level (18-32 g/L) that contributed to the worse prognosis.
引用
收藏
页码:713 / 722
页数:10
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