Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection

被引：66

作者：

Kaufmann, GR

Cunningham, P

Kelleher, AD

Zaunders, J

Carr, A

Vizzard, J

Law, M

Cooper, DA

机构：

[1] Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW 2010, Australia

[2] St Vincents Hosp, Ctr Immunol, Sydney, NSW 2010, Australia

[3] St Vincents Hosp, HIV Med Unit, Sydney, NSW 2010, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 178卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1086/314480

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study used curve-fitting techniques to detail the dynamics of human immunodeficiency virus (HIV)-1 and its relationship to circulating T lymphocyte changes in a cohort of 41 male patients (mean age 36 +/- 7 years) infected with HIV-1, The following characteristics of viral kinetics were obtained: virus load peak, 6.35 +/- 0.71 log(10) RNA copies/mL at 12.2 +/- 7.1 days; virus load drop from peak, 2.02 +/- 0.93 log(10) copies/mL; viral decay rate from peak, 0.071 +/- 0.042 log(10) RNA copies/mL/day; and steady state virus load, 4.57 +/- 0.68 log(10) copies/ mL at 135 +/- 81 days. Analysis of individual virus load curves revealed highly variable viral kinetics, Although these could be grouped into three distinct patterns, virus load and CD4 lymphocyte counts were similar in all patterns at 12 months, but the interval from infection to achievement of steady state virus load varied significantly.

引用

页码：1812 / 1815

页数：4

共 15 条

[1] Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus [J].