Hypoxia and oxidative stress during the transplantation of islets of Langerhans

被引：0

作者：

Duvillie, Bertrand ^{[1
]}

机构：

[1] INSERM, Inst Cochin, U1016, Paris, France

来源：

CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2015年 / 19卷 / 03期

关键词：

Pancreas; Transplantation; Hypoxia; Oxidative stress; Vascularization; PANCREATIC-ISLETS; CELL MASS; SURVIVAL; DIFFERENTIATION; INJURY; ADULT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypoxia alters the survival and the function of beta-cells during the graft of pancreatic islets. Blood vessels, which provide oxygen, nutriments, and growth factors, are necessary for the success of the transplantation. The transcription factor Hypoxia Inducible Factor-la is sensitive to oxygen, and its level seems to be important for insulin secretion. Although low quantities of ROS are necessary for the appropriate function of beta-cells, severe hypoxia will cause oxidative stress, which in turn will damage the cells. New pharmacological treatments can protect the beta-cells from oxidative stress.

引用

页码：53 / 57

页数：5

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