Translating Experimental Diabetic Nephropathy Studies from Mice to Men

被引：0

作者：

Breyer, Matthew D. ^{[1
]}

机构：

[1] Lilly Res Labs, Lead Generat Biol, Biotechnol Discovery Res, Indianapolis, IN 46285 USA

来源：

DIABETES AND THE KIDNEY | 2011年 / 170卷

关键词：

GLOMERULAR-FILTRATION-RATE; OXIDE SYNTHASE GENE; STAGE RENAL-DISEASE; CREATININE CLEARANCE; PLASMA CREATININE; KIDNEY-DISEASE; BLOOD-PRESSURE; KK-A(Y) MICE; MUTANT MICE; FITC-INULIN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The laboratory mouse is among the best characterized and flexible experimental platforms available for the study of diabetic nephropathy (DN). However, studies of progressive kidney disease in mice have underscored several important technical considerations for accurate phenotyping of renal function. Most mouse models of DN fail to exhibit progressive kidney disease. However, a few models have proved particularly useful. Despite the utility of these models, whether they can accurately predict clinical benefit of therapeutics in human DN remains to be established. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：156 / 164

页数：9

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