A novel HLA-A allele:: A*0257

被引：4
|
作者：
García-Ortiz, JE
Cox, ST
Sandoval-Ramirez, L
Little, AM
Marsh, SGE
Madrigal, JA
Argüello, JR
机构：
[1] Univ Autonoma Coahuila, Fac Med, Ctr Invest Biomed, Dept Inmunobiol Mol, Torreon 27000, Coahuila, Mexico
[2] Royal Free Hosp, Sch Med, Anthony Nolan Res Inst, London, England
[3] CMNO IMSS, Ctr Invest Biomed Occidente, Div Genet, Guadalajara, Jalisco, Mexico
来源：
TISSUE ANTIGENS | 2004年 / 63卷 / 01期
关键词：
HLA-A*0257; new HLA allele; reference strand-mediated conformation analysis;
D O I：
10.1111/j.1399-0039.2004.00154.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A novel human leucocyte antigen-A*02 (HLA-A*02) allele was detected by reference strand-mediated conformation analysis (RSCA) of a DNA sample from a Tarahumara individual. Direct sequencing of HLA-A locus polymerase chain reaction products identified a mutation in one of the alleles. Cloning and sequencing confirmed the presence of a new allele, A*0257 which differed from A*0206 by two nucleotides at positions 355 and 362, inducing changes in residues 95 and 97, respectively, within the peptide-binding site. Those changes suggest that allele A*0257 may have resulted from an intralocus recombination event.
引用
收藏
页码：85 / 87
页数：3
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