Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

被引：15
作者：
Xu, Derong [1 ]
Ma, Xuexiao [1 ]
Sun, Chong [1 ]
Han, Jialuo [1 ]
Zhou, Chuanli [1 ]
Wong, Sunny Hei [2 ]
Chan, Matthew T. V. [3 ,4 ]
Wu, William K. K. [3 ,4 ,5 ]
机构：
[1] Qingdao Univ, Dept Spine Surg, Affiliated Hosp, Qingdao, Peoples R China
[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
[3] Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Peter Hung Pain Res Inst, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, LKS Inst Hlth Sci, State Key Lab Digest Dis, Hong Kong, Peoples R China
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2022年 / 8卷
关键词：
CircRNAs; lower back pain; ncRNAs; intervertebral disc degeneration; CircITCH; NUCLEUS PULPOSUS CELLS; LOW-BACK-PAIN; DIAGNOSTIC BIOMARKER; MATRIX DEGRADATION; BREAST-CANCER; PROMOTES; APOPTOSIS; PROLIFERATION; PROGRESSION; QUANTIFICATION;
D O I：
10.3389/fmolb.2021.781424
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low back pain, a common medical condition, could result in severe disability and inflict huge economical and public health burden. Its pathogenesis is attributed to multiple etiological factors, including intervertebral disc degeneration (IDD). Emerging evidence suggests that circular RNAs (circRNAs), a major type of regulatory non-coding RNA, play critical roles in cellular processes that are pertinent to IDD development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition. Increasing number of translational studies also indicated that circRNAs could serve as novel biomarkers for the diagnosis of IDD and/or predicting its clinical outcomes. Our review aims to discuss the recent progress in the functions and mechanisms of newly discovered IDD-related circRNAs.
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页数：10
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