Safety and Efficacy of Human Muse Cell-Based Product for Acute Myocardial Infarction in a First-in-Human Trial

被引：48
|
作者：
Noda, Toshiyuki [1 ]
Nishigaki, Kazuhiko [2 ]
Minatoguchi, Shinya [2 ,3 ]
机构：
[1] Gifu Prefectural Gen Med Ctr, Gifu, Japan
[2] Gifu Municipal Hosp, 7-1 Kashimacho, Gifu 5008513, Japan
[3] Gifu Univ, Grad Sch Med, Dept Circulatory & Resp Adv Med, Gifu, Japan
来源：
CIRCULATION JOURNAL | 2020年 / 84卷 / 07期
关键词：
Acute myocardial infarction; Muse cell-based product; Safety; PLURIPOTENT STEM-CELLS;
D O I：
10.1253/circj.CJ-20-0307
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Because ST-elevation myocardial infarction (STEMI) extensively damages the heart, regenerative therapy with pluripotent stem cells such as multilineage-differentiating stress enduring (Muse) cells is required. Methods and Results: In a first-in-human study, 3 STEMI patients with a left ventricular ejection fraction (LVEF) <= 45% after successful percutaneous coronary intervention received intravenously 1.5x10(7) cells of a human Muse cell-based product, CL2020. The safety and efficacy on LVEF and wall motion score index (WMSI) were evaluated for 12 weeks. No adverse drug reaction was noted. LVEF and WMSI were markedly improved. Conclusions: The first-in-human intravenous administration of CL2020 was safe and markedly improved LV function in STEMI patients.
引用
收藏
页码：1189 / +
页数：14
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