Is the application of prostaglandin E1 effective for the treatment of sudden hearing loss?: An evidence-based meta-analysis

被引：17

作者：

Zhuo, Xian-Lu ^{[2
]}

Wang, Yan ^{[3
]}

Zhuo, Wen-Lei ^{[1
]}

Zhang, Xue-Yuan ^{[2
]}

机构：

[1] Third Mil Med Univ, Inst Canc, Xinqiao Hosp, Chongqing 400037, Peoples R China

[2] Third Mil Med Univ, Dept Otolaryngol, SW Hosp, Chongqing 400037, Peoples R China

[3] Third Mil Med Univ, Inst Resp Dis, Xinqiao Hosp, Chongqing 400037, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2008年 / 36卷 / 03期

关键词：

sudden hearing loss; prostglandin E-1; therapy; blood supply; meta-analysis;

D O I：

10.1177/147323000803600310

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Microvascular dysfunction in the cochlea has been considered the major cause of sudden hearing loss (SHL). For some time, prostaglandin E-1 (PGE(1)), an effective vasodilator, has been used to treat patients with SHL, however the benefits of this therapy remain unclear. The present study assessed the efficacy of PGE1 on SHL via a quantitative meta-analysis of 13 randomized controlled studies. The pooled odds ratio was 1.95 (95% confidence interval: 1.53, 2.50) and the test for overall effect (Z-value) was 5.31 (P < 0.00001), suggesting that PGE1 is an effective and promising strategy for the treatment of SHL.

引用

页码：467 / 470

页数：4

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