Partial Escape of HIV-1 from Cytotoxic T Lymphocytes during Chronic Infection

被引：6

作者：

Lewis, Martha J. ^{[1
,2
]}

Dagarag, Mirabelle ^{[1
]}

Khan, Basim ^{[1
]}

Ali, Ayub ^{[1
,2
]}

Yang, Otto O. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Infect Dis, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, AIDS Inst, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Med Genet, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 13期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; VIRAL REPLICATION; GENETIC-VARIATION; CELL RESPONSES; HLA; GAG; MUTATIONS; SELECTION; EPITOPE;

D O I：

10.1128/JVI.06724-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."

引用

页码：7459 / 7463

页数：5

共 38 条

[31] Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells [J].