Partial Escape of HIV-1 from Cytotoxic T Lymphocytes during Chronic Infection

被引：6

作者：

Lewis, Martha J. ^{[1
,2
]}

Dagarag, Mirabelle ^{[1
]}

Khan, Basim ^{[1
]}

Ali, Ayub ^{[1
,2
]}

Yang, Otto O. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Infect Dis, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, AIDS Inst, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Med Genet, Los Angeles, CA 90095 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 13期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; VIRAL REPLICATION; GENETIC-VARIATION; CELL RESPONSES; HLA; GAG; MUTATIONS; SELECTION; EPITOPE;

D O I：

10.1128/JVI.06724-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."

引用

收藏

页码：7459 / 7463

页数：5

相关论文

共 38 条

[1] Half-genome human immunodeficiency virus type 1 constructs for rapid production of reporter viruses [J].

Ali, A ;

Jamieson, BD ;

Yang, OO .

JOURNAL OF VIROLOGICAL METHODS, 2003, 110 (02) :137-142

[2] A novel small reporter gene and HIV-1 fitness assay [J].

Ali, Ayub ;

Yang, Otto O. .

JOURNAL OF VIROLOGICAL METHODS, 2006, 133 (01) :41-47

[3] Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [J].

Allen, TM ;

Altfeld, M ;

Geer, SC ;

Kalife, ET ;

Moore, C ;

O'Sullivan, KM ;

DeSouza, I ;

Feeney, ME ;

Eldridge, RL ;

Maier, EL ;

Kaufmann, DE ;

Lahaie, MP ;

Reyor, L ;

Tanzi, G ;

Johnston, MN ;

Brander, C ;

Draenert, R ;

Rockstroh, JK ;

Jessen, H ;

Rosenberg, ES ;

Mallal, SA ;

Walker, BD .

JOURNAL OF VIROLOGY, 2005, 79 (21) :13239-13249

[4] HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus [J].

Altfeld, M ;

Allen, TM ;

Yu, XG ;

Johnston, MN ;

Agrawal, D ;

Korber, BT ;

Montefiori, DC ;

O'Connor, DH ;

Davis, BT ;

Lee, PK ;

Maier, EL ;

Harlow, J ;

Goulder, PJR ;

Brander, C ;

Rosenberg, ES ;

Walker, BD .

NATURE, 2002, 420 (6914) :434-439

[5]

[Anonymous], 2005, PHYLIP (phylogeny inference package) version 3.6

[6] Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 gag vaccination [J].

Balamurugan, Arumugam ;

Lewis, Martha J. ;

Kitchen, Christina M. R. ;

Robertson, Michael N. ;

Shiver, John W. ;

Daar, Eric S. ;

Pitt, Jacqueline ;

Ali, Ayub ;

Ng, Hwee L. ;

Currier, Judith S. ;

Yang, Otto O. .

JOURNAL OF VIROLOGY, 2008, 82 (06) :2784-2791

[7] Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus [J].

Borrow, P ;

Lewicki, H ;

Wei, XP ;

Horwitz, MS ;

Peffer, N ;

Meyers, H ;

Nelson, JA ;

Gairin, JE ;

Hahn, BH ;

Oldstone, MBA ;

Shaw, GM .

NATURE MEDICINE, 1997, 3 (02) :205-211

[8] Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein [J].

Boutwell, Christian L. ;

Rowley, Christopher F. ;

Essex, M. .

JOURNAL OF VIROLOGY, 2009, 83 (06) :2460-2468

[9] HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY [J].

COFFIN, JM .

SCIENCE, 1995, 267 (5197) :483-489

[10] Compensatory mutation partially restores fitness and delays reversion of escpe mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection [J].

Crawford, Hayley ;

Prado, Julia G. ;

Leslie, Alasdair ;

Hue, Stephane ;

Honeyborne, Isobella ;

Reddy, Sharon ;

van der Stok, Mary ;

Mncube, Zenele ;

Brander, Christian ;

Rousseau, Christine ;

Mullins, James I. ;

Kaslow, Richard ;

Goepfert, Paul ;

Allen, Susan ;

Hunter, Eric ;

Mulenga, Joseph ;

Kiepiela, Photini ;

Walker, Bruce D. ;

Goulder, Philip J. R. .

JOURNAL OF VIROLOGY, 2007, 81 (15) :8346-8351

← 1 2 3 4 →