Local Allergic Rhinitis Revisited

被引：14

作者：

Vardouniotis, Alexios ^{[1
]}

Doulaptsi, Maria ^{[2
]}

Aoi, Nori ^{[3
]}

Karatzanis, Alexander ^{[2
]}

Kawauchi, Hideyuki ^{[3
]}

Prokopakis, Emmanuel ^{[2
]}

机构：

[1] St Marys Treatment Ctr, ENT Dept, Portsmouth, Hants, England

[2] Univ Crete, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Iraklion, Crete, Greece

[3] Shimane Univ, Fac Med, Dept Otorhinolaryngol, Matsue, Shimane, Japan

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2020年 / 20卷 / 07期

关键词：

Local allergic rhinitis; Allergic rhinitis; Nasal IgE; Nasal provocation test; Allergen immunotherapy; CLASS SWITCH RECOMBINATION; NASAL B-CELLS; IGE ANTIBODIES; STAPHYLOCOCCUS-AUREUS; NONALLERGIC RHINITIS; CLINICAL CHARACTERISTICS; CHRONIC RHINOSINUSITIS; IDIOPATHIC RHINITIS; EUROPEAN ACADEMY; D; PTERONYSSINUS;

D O I：

10.1007/s11882-020-00925-5

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of ReviewLocal allergic rhinitis (LAR) represents a diagnostic and therapeutic challenge for clinicians. Even though it affects a considerable number of chronic rhinitis patients and a significant number of articles regarding prevalence, evolution, diagnosis, and treatment have been published, the condition remains still largely unrecognized and therefore misdiagnosed and mistreated.Recent FindingsLAR is a unique form of chronic rhinitis; it is neither classical allergic rhinitis (AR) nor non-allergic rhinitis (NAR). The symptoms, duration, severity, and complications of LAR are similar to those of AR and can affect adults and children. Thus, a portion of patients diagnosed with NAR or chronic rhinitis of unknown etiology may have LAR. The relationship between LAR inflammation and systemic allergic inflammation is unclear. Patients are frequently misdiagnosed with idiopathic NAR, and distinguishing between both entities is difficult without specific diagnostic tests. Underdiagnosis of LAR has implications on the management of these patients, as they are deprived of allergen immunotherapy (AIT) that has been demonstrated to modulate the immune mechanisms underlying allergic diseases.SummaryThis review aims to comprehensively summarize the current knowledge on LAR and address unmet needs in the areas of disease diagnosis and treatment.

引用

页数：7

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