Creating permissive microenvironments for stem cell transplantation into the central nervous system

被引：82
作者：
Kim, Howard [1 ,2 ]
Cooke, Michael J. [2 ,3 ]
Shoichet, Molly S. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[2] Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada
[4] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
TRENDS IN BIOTECHNOLOGY | 2012年 / 30卷 / 01期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
SPINAL-CORD-INJURY; NEURAL PROGENITOR CELLS; EXTRACELLULAR-MATRIX MOLECULES; GROWTH-FACTOR; IN-VITRO; NEURONAL DIFFERENTIATION; CHITOSAN CHANNELS; RAT; SCAFFOLDS; HYDROGELS;
D O I：
10.1016/j.tibtech.2011.07.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are promising because they can repopulate lost or damaged cells and tissues. However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues. This review provides an overview of tissue engineering strategies to improve stem cell therapies by providing a defined microenvironment during transplantation. The use of biomaterials for physical support, growth factor delivery, and cellular co-transplantation are discussed. Providing the proper environment for stem cell survival and host tissue integration is crucial in realizing the full potential of these cells in CNS repair strategies.
引用
收藏
页码：55 / 63
页数：9
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