Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual C?H Bond Cleavage of an Arene and Acetonitrile

被引：283

作者：

Wu, Tao ^{[1
]}

Mu, Xin ^{[1
]}

Liu, Guosheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 52期

基金：

中国国家自然科学基金;

关键词：

acetonitrile; alkenes; arylalkylation; C?H activation; palladium; CARBON-HYDROGEN BONDS; H ACTIVATION; MOLECULAR-OXYGEN; PD(II)-CATALYZED OLEFINATION; N-FLUOROBENZENESULFONIMIDE; UNACTIVATED ALKENES; ALPHA-ARYLATION; SOLE OXIDANT; DIAMINATION; COMPLEXES;

D O I：

10.1002/anie.201104575

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Not one but two: The title reaction proceeds through the dual C-H bond cleavage of both aniline and acetonitrile (see scheme). The reaction affords a variety of cyano-bearing indolinones in excellent yield. Mechanistic studies demonstrate that this reaction involves a fast arylation of the olefin and a rate-determining C-H activation of the acetonitrile. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：12578 / 12581

页数：4

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