Hepatitis E virus-associated aplastic anaemia: The first case of its kind

被引：49

作者：

Shah, Shahida Amjad Riaz ^{[2
]}

Lal, Amreek ^{[3
]}

Idrees, Muhammad ^{[1
]}

Hussain, Abrar ^{[1
]}

Jeet, Charan ^{[3
]}

Malik, Fayyaz A. ^{[4
]}

Iqbal, Zafar ^{[5
]}

Rehman, Habib Ur

机构：

[1] Univ Punjab, Natl Ctr Excellence Mol Biol, Div Mol Virol, Lahore 53700, Pakistan

[2] Sheikh Zayed Med Complex, Dept Hematol, Lahore, Pakistan

[3] Sidu Med Coll, Dept Hematol, Sidu Sharif Swat, Pakistan

[4] Independent Med Coll, Dept Pathol, Faisalabad, Pakistan

[5] Sheikh Zayed Med Complex, Dept Med, Lahore, Pakistan

来源：

JOURNAL OF CLINICAL VIROLOGY | 2012年 / 54卷 / 01期

关键词：

Aplastic anaemia; Hepatitis E virus; Immunosupressive therapy; INFECTION; PAKISTAN;

D O I：

10.1016/j.jcv.2012.02.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here we report the case of a 32-year-old Pakistani male, who developed severe aplastic anaemia after a severe attack of acute hepatitis E virus (HEV) infection. His laboratory test values were not in normal ranges. The liver enzymes were elevated. Serologic and/or molecular-based tests for hepatitis A, B, C, D, G, transfusion transmitted virus (TTV) and B19 were negative, whereas anti-HEV IgM and HEV RNA polymerase chain reaction (PCR) was also detected in the patient sample. The patient received immunosuppressive therapy for 6 months; however, he did not show response to this kind of therapy. The results of our case clearly show the causative role of HEV in the development of aplastic anaemia that might not be ignored. (C) 2012 Elsevier B. V. All rights reserved.

引用

页码：96 / 97

页数：2

共 15 条

[1]

Adil S N, 2001, J Pak Med Assoc, V51, P443

[2] Frequency of HEV contamination in sewerage waters in Pakistan [J].

Ahmad, Tahir ;

Waheed, Yasir ;

Tahir, Sadia ;

Safi, Sher Zaman ;

Fatima, Kaneez ;

Afzal, Muhammad Sohail ;

Farooqi, Zia-ur-Rehman ;

Qadri, Ishtiaq .

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2010, 4 (12) :842-845

[3] Epidemiology of hepatitis E virus infection [J].

Balayan, MS .

JOURNAL OF VIRAL HEPATITIS, 1997, 4 (03) :155-165

[4] Hepatitis-associated aplastic anemia [J].

Brown, KE ;

Tisdale, J ;

Barrett, AJ ;

Dunbar, CE ;

Young, NS .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1059-1064

[5]

Farahmand F., 2005, Govaresh, V10, P54

[6] APLASTIC-ANEMIA FOLLOWING VIRAL-HEPATITIS - REPORT OF 2 FATAL CASES AND LITERATURE REVIEW [J].

HAGLER, L ;

PASTORE, RA ;

BERGIN, JJ .

MEDICINE, 1975, 54 (02) :139-164

[7] Aplastic anemia associated with interferon alpha 2a in a patient with chronic hepatitis C virus infection: a case report [J].

Savvas Ioannou ;

Gregorios Hatzis ;

Ioanna Vlahadami ;

Michael Voulgarelis .

Journal of Medical Case Reports, 4 (1)

[8] STUDY OF AN EPIDEMIC OF NON-A, NON-B HEPATITIS - POSSIBILITY OF ANOTHER HUMAN HEPATITIS-VIRUS DISTINCT FROM POST-TRANSFUSION NON-A, NON-B TYPE [J].

KHUROO, MS .

AMERICAN JOURNAL OF MEDICINE, 1980, 68 (06) :818-824

[9]

LORENZ E, 1955, Wien Med Wochenschr, V105, P19

[10]

Meng XJ, 2003, CURR TOP MICROBIOL, V278, P185

← 1 2 →