Highly efficient one-pot synthesis of trisubstituted imidazoles under catalyst-free conditions

被引：24

作者：

Azizi, Najmadin ^{[1
]}

Dado, Nairreh ^{[1
]}

Amiri, Alireza Khajeh ^{[1
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2012年 / 90卷 / 02期

关键词：

aldehyde; benzil; imidazole; atom economic; solvent effect; catalyst free; PRACTICAL SYNTHESIS; ALDEHYDES; CONDENSATION; CARBENES; SYSTEM; WATER;

D O I：

10.1139/V11-141

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Operationally simple, atom economical, and scalable synthesis of 2,4,5-trisubstituted imidazoles from benzil, aldehydes, and ammonium acetate is shown to proceed readily in methanol with high yield. The scope of the reaction is quite broad; a variety of aromatic and aliphatic activated and unactivated aldehydes have all been shown to be viable substrates for this reaction. Excellent yields and purity were obtained by washing the products with hot ethanol.

引用

收藏

页码：195 / 198

页数：4

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