Heart Failure Subtypes and Cardiomyopathies in Women

被引：40

作者：

DeFilippis, Ersilia M. ^{[1
]}

Beale, Anna ^{[2
]}

Martin, Trejeeve ^{[3
]}

Agarwal, Anubha ^{[4
]}

Elkayam, Uri ^{[5
]}

Lam, Carolyn S. P. ^{[6
,7
]}

Hsich, Eileen ^{[3
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Div Cardiol, New York, NY 10032 USA

[2] Alfred Hosp, Dept Cardiol, Melbourne, Vic, Australia

[3] Cleveland Clin, Dept Cardiol, Cleveland, OH 44106 USA

[4] Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA

[5] Univ Southern Calif, Keck Sch Med, Div Cardiovasc Med, Los Angeles, CA 90007 USA

[6] Natl Heart Ctr Singapore, Singapore, Singapore

[7] Duke Natl Univ Singapore, Singapore, Singapore

来源：

CIRCULATION RESEARCH | 2022年 / 130卷 / 04期

基金：

英国医学研究理事会;

关键词：

cardiomyopathies; estrogens; heart failure; peripartum; women; PRESERVED EJECTION FRACTION; CARDIAC RESYNCHRONIZATION THERAPY; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; BAROREFLEX ACTIVATION THERAPY; CONVERTING ENZYME-INHIBITORS; LEFT-VENTRICULAR DYSFUNCTION; PULMONARY-ARTERY PRESSURE; SEX-RELATED DIFFERENCES; CLINICAL CHARACTERISTICS; PRIMARY PREVENTION;

D O I：

10.1161/CIRCRESAHA.121.319900

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure affects over 2.6 million women and 3.4 million men in the United States with known sex differences in epidemiology, management, response to treatment, and outcomes across a wide spectrum of cardiomyopathies that include peripartum cardiomyopathy, hypertrophic cardiomyopathy, stress cardiomyopathy, cardiac amyloidosis, and sarcoidosis. Some of these sex-specific considerations are driven by the cellular effects of sex hormones on the renin-angiotensin-aldosterone system, endothelial response to injury, vascular aging, and left ventricular remodeling. Other sex differences are perpetuated by implicit bias leading to undertreatment and underrepresentation in clinical trials. The goal of this narrative review is to comprehensively examine the existing literature over the last decade regarding sex differences in various heart failure syndromes from pathophysiological insights to clinical practice.

引用

页码：436 / 454

页数：19

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