Cluster randomized controlled trials

被引：111

作者：

Puffer, S ^{[1
]}

Torgerson, DJ ^{[1
]}

Watson, J ^{[1
]}

机构：

[1] Univ York, Dept Hlth Sci, York Trials Unit, Area 4, York YO10 5DD, N Yorkshire, England

来源：

JOURNAL OF EVALUATION IN CLINICAL PRACTICE | 2005年 / 11卷 / 05期

关键词：

cluster; controlled trial; methodology; randomized;

D O I：

10.1111/j.1365-2753.2005.00568.x

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Cluster randomized controlled trial (RCT), in which groups or clusters of individuals rather than individuals themselves are randomized, are increasingly common. Indeed, for the evaluation of certain types of intervention (such as those used in health promotion and educational interventions) a cluster randomized trial is virtually the only valid approach. However, cluster trials are generally more difficult to design and execute than individually randomized studies, and some design features of a cluster trial may make it particularly vulnerable to a range of threats that can introduce bias. In this paper we discuss the issues that can lead to bias in cluster randomized trials and conclude with some suggestions for avoiding these problems.

引用

页码：479 / 483

页数：5

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