Calorie restriction and prevention of age-associated chronic disease

被引：213
作者：
Omodei, Daniela [1 ,2 ,3 ]
Fontana, Luigi [1 ,2 ,4 ]
机构：
[1] Washington Univ, Sch Med, Div Geriatr & Nutr Sci, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA
[3] CEINGE Biotecnol Avanzate, Naples, Italy
[4] Ist Super Sanita, Div Nutr & Aging, I-00161 Rome, Italy
来源：
FEBS LETTERS | 2011年 / 585卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Calorie restriction; Aging; Chronic disease; Prevention; EXTENDS LIFE-SPAN; GENETICALLY HETEROGENEOUS MICE; OXIDATIVE STRESS; RHESUS-MONKEYS; DIETARY RESTRICTION; GROWTH-HORMONE; CARDIOVASCULAR-DISEASE; BODY-TEMPERATURE; THYROID-HORMONES; AGING PROCESS;
D O I：
10.1016/j.febslet.2011.03.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1537 / 1542
页数：6
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