Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

被引：12
作者：
Bojkova, Bianka [1 ]
Kubatka, Peter [2 ,3 ]
Qaradakhi, Tawar [4 ]
Zulli, Anthony [4 ]
Kajo, Karol [5 ,6 ]
机构：
[1] Pavol Jozef Safarik Univ Kosice, Fac Sci, Inst Biol & Ecol, Dept Anim Physiol, Srobarova 2, Kosice, Slovakia
[2] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Mala Hora 4, Martin 03601, Slovakia
[3] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Dept Expt Carcinogenesis,Div Oncol, Mala Hora 4C, Martin, Slovakia
[4] Victoria Univ, Inst Hlth & Sport IHES, Melbourne, Vic 3011, Australia
[5] St Elisabeth Oncol Inst, Heydukova 10, Bratislava 81108, Slovakia
[6] Slovak Acad Sci, Biomed Res Ctr, Dubravska Cesta 9, Bratislava 84505, Slovakia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期
关键词：
melatonin; cancer; NSAIDs; statins; antidiabetics; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PINEAL HORMONE MELATONIN; ACTIVATED RECEPTOR-GAMMA; INDUCED MAMMARY CARCINOGENESIS; COLORECTAL-CANCER CELLS; DI BELLA METHOD; INHIBIT SKIN CARCINOGENESIS; PHASE-II TRIAL; BREAST-CANCER; PROSTATE-CANCER;
D O I：
10.3390/ijms19123910
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research.
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页数：34
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