Mechanical forces modulate alveolar epithelial phenotypic expression

被引:23
作者
Dobbs, LG
Gutierrez, JA
机构
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94118 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[3] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY | 2001年 / 129卷 / 01期
关键词
mechanical forces; lung development; type II cells; lung; surfactant; gene regulation; second messengers; secretion; differentiation; phenotypic expression;
D O I
10.1016/S1095-6433(01)00322-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
physical forces play an important role in modulating lung development. growth, compliance, differentiation and metabolism. Both tonic distension and phasic changes in volume occur during development and after birth. Morphometric studies have shown that alveolar epithelial cells are distended during lung expansion from functional residual capacity. In both in vivo and in vitro model systems, mechanical distension stimulates surfactant secretion. Drawing on the results of developmental anomalies and experiments in vivo, we and others have generated the underlying hypothesis that mechanical distension promotes expression of the type cell phenotype and inhibits expression that of the type II; contraction has the opposite effects. The results of recent experiments, using both cultured type II cells from adult rodents and fetal lung explant tissue to test this hypothesis, provide support. The molecular and biochemical mechanisms by which physical forces affect lung functions are currently under investigation. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:261 / 266
页数:6
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