Comparison of Differential Expression of P2Y12 Receptor in Culprit Coronary Plaques in Patients With Acute Myocardial Infarction Versus Stable Angina Pectoris

被引：17
作者：
Lee, Cheol Whan [1 ]
Hwang, Ilseon [4 ]
Park, Chan-Sik [2 ]
Lee, Hyangsin [3 ]
Park, Duk-Woo [1 ]
Kang, Su-Jin [1 ]
Lee, Seung-Whan [1 ]
Kim, Young-Hak [1 ]
Park, Seong-Wook [1 ]
Park, Seung-Jung [1 ]
机构：
[1] Univ Ulsan, Dept Med, Seoul, South Korea
[2] Univ Ulsan, Dept Pathol, Asan Med Ctr, Seoul, South Korea
[3] Univ Ulsan, Asan Inst Life Sci, Seoul, South Korea
[4] Keimyung Univ, Dept Pathol, Sch Med, Taegu, South Korea
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2011年 / 108卷 / 06期
关键词：
SMOOTH-MUSCLE-CELLS; ARTERY-DISEASE; PLATELET INHIBITION; ACTIVE METABOLITE; CLOPIDOGREL; INTERVENTION; P2Y12;
D O I：
10.1016/j.amjcard.2011.05.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P2Y(12) receptor antagonists may have pleiotropic benefits. Little is known, however, about the expression of P2Y(12) receptors in coronary atherosclerotic plaques. We investigated the expression of P2Y(12) receptor in coronary atherectomy tissues retrieved from patients with acute myocardial infarction (AM I) or stable angina pectoris (SAP). Tissue specimens were collected from 35 patients with AMI and 19 with SAP who underwent directional coronary atherectomy. Specimens were analyzed immunohistochemically using antibodies specific to P2Y(12) receptor and to markers of endothelial cells, macrophages, and smooth muscle cells. The 2 groups had similar baseline clinical characteristics. Plaque types were more likely to be cellular in the AMI group. The proportion of areas immunopositive for alpha-smooth muscle actin was smaller but those positive for CD31 and CD68 were larger in the AMI than in the SAP group. In addition, the relative area immunopositive for P2Y(12) receptor was significantly larger for AlVII than SAP (1.1 +/- 0.9% vs 0.5 +/- 0.4%, respectively, p <0.001). P2Y(12) receptor positivity coincided with areas positive for CD31 and at-smooth muscle actin. In conclusion, P2Y(12) receptor is present in coronary atherosclerotic plaques and is increased in culprit plaques of patients with AMI. P2Y(12) receptor may play a role in plaque destabilization. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;108:799-803)
引用
收藏
页码：799 / 803
页数：5
相关论文
共 19 条
[1]   Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease [J].
Angiolillo, DJ ;
Fernandez-Ortiz, A ;
Bernardo, E ;
Ramírez, C ;
Sabaté, M ;
Jimenez-Quevedo, P ;
Hernández, R ;
Moreno, R ;
Escaned, J ;
Alfonso, F ;
Bañuelos, C ;
Costa, MA ;
Bass, TA ;
Macaya, C .
DIABETES, 2006, 55 (03) :780-784
[2]   Level of Adenosine Diphosphate Receptor P2Y12 Blockade During Percutaneous Coronary Intervention Predicts the Extent of Endothelial Injury, Assessed by Circulating Endothelial Cell Measurement [J].
Bonello, Laurent ;
Harhouri, Karim ;
Sabatier, Florence ;
Camoin-Jau, Laurence ;
Arnaud, Laurent ;
Baumstarck-Barrau, Karine ;
Ait-Mokhtar, Omar ;
Roubille, Francois ;
Piot, Christophe ;
Lesavre, Nathalie ;
Paganelli, Franck ;
Dignat-George, Francoise .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (13) :1024-1031
[3]   Inhibition of plasma-dependent monocyte chemokinesis and cytokine-triggered endothelial activation for neutrophil transmigration by administration of clopidogrel in man [J].
Dunzendorfer, S ;
Reinisch, CM ;
Kaneider, NC ;
Pechlaner, C ;
Wiedermann, CJ .
ACTA MEDICA AUSTRIACA, 2002, 29 (03) :100-106
[4]   Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease -: Evidence for antioxidant and antiinflammatory effects [J].
Heitzer, Thomas ;
Rudolph, Volker ;
Schwedhelm, Edzard ;
Karstens, Manuela ;
Sydow, Karsten ;
Ortak, Michelle ;
Tschentscher, Peter ;
Meinertz, Thomas ;
Boeger, Rainer ;
Baldus, Stephan .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (07) :1648-1652
[5]   The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature [J].
Hogberg, Carl ;
Svensson, Helen ;
Gustafsson, Ronny ;
Eyjolfsson, Atli ;
Erlinge, David .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 142 (02) :187-192
[6]   Endothelial action of thienopyridines and thienopyrimidinones isolated guinea in the pig heart [J].
Jakubowski, A ;
Chlopicki, S ;
Olszanecki, R ;
Jawien, J ;
Lomnicka, M ;
Dupin, JP ;
Gryglewski, RJ .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2005, 72 (02) :139-145
[7]   Directional coronary atherectomy for the treatment of acute myocardial infarction [J].
Kurisu, S ;
Sato, H ;
Tateishi, H ;
Kawagoe, T ;
Ishihara, M ;
Shimatani, Y ;
Sakai, K ;
Ueda, K ;
Matsuura, H .
AMERICAN HEART JOURNAL, 1997, 134 (03) :345-350
[8]  
McKnight J, 2001, W V Med J, V97, P109
[9]   High Versus Standard Clopidogrel Maintenance Dose After Percutaneous Coronary Intervention and Effects on Platelet Inhibition, Endothelial Function, and Inflammation Results of the ARMYDA-150 mg (Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty) Randomized Study [J].
Patti, Giuseppe ;
Grieco, Domenico ;
Dicuonzo, Giordano ;
Pasceri, Vincenzo ;
Nusca, Annunziata ;
Di Sciascio, Germano .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (07) :771-778
[10]   Structure and stereochemistry of the active metabolite of clopidogrel [J].
Pereillo, JM ;
Maftouh, M ;
Andrieu, A ;
Uzabiaga, MF ;
Fedeli, O ;
Savi, P ;
Pascal, M ;
Herbert, JM ;
Maffrand, JP ;
Picard, C .
DRUG METABOLISM AND DISPOSITION, 2002, 30 (11) :1288-1295
12