Expression of the AMPA-type glutamate receptor subunits in the chick optic tectum changes biphasically after retinal deafferentation

被引：9
作者：
Pires, RS
Ferro, ES
Britto, LRG
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Histol & Embryol, BR-05508900 Sao Paulo, Brazil
来源：
BRAIN RESEARCH | 1998年 / 810卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
glutamatergic system; ionotropic receptor; neurotransmitter; optic tectum; visual pathway;
D O I：
10.1016/S0006-8993(98)00937-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effects of retinal lesions on the expression of AMPA-type glutamate receptor (GluR) subunits in the chick optic tectum were evaluated with immunohistochemistry and immunoblotting.. Expression of GluR1 and GluR2/3 subunits decreased in the deafferented tectum after 2 days and increased after 7 days postlesion. These results suggest biphasic effects of retinal lesions upon the expression of GluR subunits, possibly due to removal of the glutamatergic input from the retina. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：283 / 287
页数：5
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