Anti-adipogenic and anti- diabetic effects of cis-3′,4′-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro

被引：30

作者：

Choi, Ra-Yeong ^{[1
]}

Nam, Sang-Jip ^{[2
,8
]}

Ham, Ju Ri ^{[1
]}

Lee, Hae-In ^{[3
]}

Yee, Sung-Tae ^{[4
,8
]}

Kang, Kyung-Yun ^{[4
]}

Seo, Kwon-Il ^{[5
]}

Lee, Ju-Hye ^{[6
]}

Kim, Myung-Joo ^{[7
]}

Lee, Mi-Kyung ^{[1
,8
]}

机构：

[1] Sunchon Natl Univ, Dept Food & Nutr, 255 Jungang Ro, Sunchon 57922, Jeonnam, South Korea

[2] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea

[3] Mokpo Marin Food Ind Res Ctr, Mokpo 58621, South Korea

[4] Sunchon Natl Univ, Coll Pharm, Sunchon 57922, South Korea

[5] Dong A Univ, Dept Biotechnol, Busan 49315, South Korea

[6] Natl Inst Agr Sci, Rural Dev Adm, Funct Food & Nutr Div, Wonju 55365, South Korea

[7] Suseong Coll, Dept Bakery & Barista, Daegu 42078, South Korea

[8] Suncheon Res Ctr Nat Med, Sunchon 57922, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 19期

关键词：

Adipocytes; Adipogenesis; Anti-diabetes; Anti-obesity; Peucedanum japonicum Thunb leaves; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION; TRANSCRIPTIONAL CONTROL; 3T3-L1; CELLS; OBESITY; EXPRESSION; EXTRACTS; HYPERGLYCEMIA; COUMARINS; DIESTER;

D O I：

10.1016/j.bmcl.2016.08.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (3' and 5' mu M) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBP alpha, PPAR gamma and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential alpha-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：4655 / 4660

页数：6

共 38 条

[21] Partially purified Peucedanum japonicum Thunb extracts exert anti-obesity effects in vitro [J].

Nugara, Ruwani N. ;

Inafuku, Masashi ;

Iwasaki, Hironori ;

Oku, Hirosuke .

NUTRITION, 2014, 30 (05) :575-583

[22] Effect of Peucedanum japonicum Thunb on the Expression of Obesity-Related Genes in Mice on a High-Fat Diet [J].

Nukitrangsan, Natthanan ;

Okabe, Takafumi ;

Toda, Takayoshi ;

Inafuku, Masashi ;

Iwasaki, Hironori ;

Yanagita, Teruyoshi ;

Oku, Hirosuke .

JOURNAL OF OLEO SCIENCE, 2011, 60 (10) :527-536

[23] Peucedanum japonicum Thunb Inhibits High-fat Diet Induced Obesity in Mice [J].

Okabe, Takafumi ;

Toda, Takayoshi ;

Nukitrangsan, Natthanan ;

Inafuku, Masashi ;

Iwasaki, Hironori ;

Oku, Hirosuke .

PHYTOTHERAPY RESEARCH, 2011, 25 (06) :870-877

[24] C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis [J].

Payne, Victoria A. ;

Au, Wo-Shing ;

Lowe, Christopher E. ;

Rahman, Shaikh M. ;

Friedman, Jacob E. ;

O'Rahilly, Stephen ;

Rochford, Justin J. .

BIOCHEMICAL JOURNAL, 2010, 425 :215-223

[25] Cell line models for differentiation: preadipocytes and adipocytes [J].

Poulos, Sylvia P. ;

Dodson, Michael V. ;

Hausman, Gary J. .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (10) :1185-1193

[26] Transcriptional control of adipogenesis [J].

Rangwala, SM ;

Lazar, MA .

ANNUAL REVIEW OF NUTRITION, 2000, 20 :535-559

[27] Pear pomace water extract inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes [J].

Rhyu, Jin ;

Kim, Min Sook ;

You, Mi-Kyoung ;

Bang, Mi-Ae ;

Kim, Hyeon-A .

NUTRITION RESEARCH AND PRACTICE, 2014, 8 (01) :33-39

[28] Molecular regulation of adipogenesis [J].

Rosen, ED ;

Spiegelman, BM .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 :145-171

[29] AMPK, insulin resistance, and the metabolic syndrome [J].

Ruderman, Neil B. ;

Carling, David ;

Prentki, Marc ;

Cacicedo, Jose M. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (07) :2764-2772

[30] Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice [J].

Sim, Mi-Ok ;

Ham, Ju Ri ;

Lee, Hae-In ;

Seo, Kwon-Il ;

Lee, Mi-Kyung .

CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 216 :9-16

← 1 2 3 4 →