Random copolymers of N-vinylpyrrolidone and 6-crotonoyl aminohexanoic acid: synthesis, purification, molecular and hydrodynamic characteristics

被引：0

作者：

Krasikov, V. D. ^{[1
]}

Borisenko, M. S. ^{[1
]}

Ershov, A. Y. ^{[1
]}

Gorshkov, N. I. ^{[1
]}

Malakhova, I. I. ^{[1
]}

Bezrukova, M. A. ^{[1
]}

Kipper, A. I. ^{[1
]}

Solovskii, M. V. ^{[1
]}

机构：

[1] Russian Acad Sci IMC RAS, Inst Macromol Cpds, Fed State Budgetary Inst Sci, St Petersburg, Russia

来源：

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION | 2018年 / 23卷 / 08期

关键词：

Water souble co-polymers; N-vinylpyrrolidone; beta-crotonoylaminocaproic acid; HPLC; TLC; NMR and IR spectroscopy; viscosimetry; Mark-Kuhn-Howink-Sakurada constants; translation diffusion; velocity sedimentation; dynamic light scattering; MACROMOLECULES; BEHAVIOR;

D O I：

10.1080/1023666X.2018.1505588

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Synthetic methods for random copolymers of N-vinylpyrrolidone and 6-crotonoyl aminohexanoic acid (6-CAHA) were developed. These carboxyl-containing water-soluble copolymers are the promising drug carriers. The technique for purification of polymers of this type from admixed comonomer (hydrophobic 6-CAHA) was proposed. Molecular masses, sizes, and molecular mass distributions were determined by HPLC, optical and hydrodynamic methods.

引用

页码：730 / 739

页数：10

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