Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients

被引：44

作者：

Kawasaki, Eiji ^{[1
]}

Nakamura, Kan ^{[1
]}

Kuriya, Genpei ^{[2
]}

Satoh, Tsuyoshi ^{[2
]}

Kobayashi, Masakazu ^{[2
]}

Kuwahara, Hironaga ^{[2
]}

Abiru, Norio ^{[2
]}

Yamasaki, Hironori ^{[3
]}

Matsuura, Nobuo ^{[4
]}

Miura, Junnosuke ^{[5
]}

Uchigata, Yasuko ^{[5
]}

Eguchi, Katsumi ^{[2
]}

机构：

[1] Nagasaki Univ Hosp, Dept Metab Diabet & Clin Nutr, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Unit Translat Med, Dept Endocrinol & Metab, Nagasaki 852, Japan

[3] Nagasaki Univ, Ctr Hlth & Communicating Med, Nagasaki 852, Japan

[4] Seitoku Univ, Dept Early Childhood Educ, Matsudo, Chiba, Japan

[5] Tokyo Womens Med Univ, Sch Med, Ctr Diabet, Tokyo, Japan

来源：

CLINICAL IMMUNOLOGY | 2011年 / 138卷 / 02期

关键词：

Autoantibodies; Epitope; Fulminant; HLA; Type; 1; diabetes; Zinc transporter-8; PANCREATIC BETA-CELL; AUTOANTIBODIES; FULMINANT; SLC30A8; INSULIN; ASSOCIATION; GENOTYPES; AGE;

D O I：

10.1016/j.clim.2010.10.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 childhood-onset, 97 adult-onset, and 85 fulminant T1D. The ZnT8A frequency was higher in childhood-onset patients and decreased with increasing age of onset from 70% to 24% (P-trend <0.005). None of the patients with fulminant T1D was positive for ZnT8A. There were at least two distinct ZnT8A epitope patterns associated with the aa325-restriction, childhood-onset patients have aa325-nonrestricted response more frequently compared to the adult-onset group (P<0.05). The level of ZnT8A was inversely associated with the copy number of HLA-DR4 allele (P<0.05). These results suggest differences in the humoral autoreactivity to ZnT8 depending on the clinical phenotype, which should provide strategy for autoantibody measurement in subjects to allow early diagnosis of autoimmune T1D. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：146 / 153

页数：8

共 22 条

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