Advances in nonhuman primate models of autism: Integrating neuroscience and behavior

被引:52
作者
Bauman, M. D. [1 ,2 ,3 ,4 ]
Schumann, C. M. [1 ,2 ]
机构
[1] Univ Calif Davis, UC Davis MIND Inst, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA
[3] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[4] UC Davis MIND Inst, Biosci Bldg 1416,2805 50th St, Sacramento, CA 95817 USA
关键词
Animal model; Autism spectrum disorder; Rhesus monkey; Preclinical; MATERNAL IMMUNE ACTIVATION; NEONATAL AMYGDALA LESIONS; DIAGNOSTIC OBSERVATION SCHEDULE; BTBR MOUSE MODEL; SPECTRUM DISORDERS; INTRANASAL OXYTOCIN; SOCIAL-BEHAVIOR; ANIMAL-MODELS; PRENATAL INFECTION; BRAIN-DEVELOPMENT;
D O I
10.1016/j.expneurol.2017.07.021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research are needed to (i) identify and evaluate putative causes of ASD, (ii) determine the underlying neurobiological mechanisms, (iii) develop and test novel therapeutic approaches and (iv) ultimately translate basic research into safe and effective clinical practices. However, modeling a uniquely human brain disorder, such as ASD, will require sophisticated animal models that capitalize on unique advantages of diverse species including drosophila, zebra fish, mice, rats, and ultimately, species more closely related to humans, such as the nonhuman primate. Here we discuss the unique contributions of the rhesus monkey (Macaca mulatto) model to ongoing efforts to understand the neurobiology of the disorder, focusing on the convergence of brain and behavior outcome measures that parallel features of human ASD.
引用
收藏
页码:252 / 265
页数:14
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