Liquid chromatographic analysis of certain commercial formulations for non-opioid analgesics

被引：19
作者：
Bhushan, R. [1 ]
Gupta, Deepak [1 ]
Mukherjee, Aparna [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India
来源：
BIOMEDICAL CHROMATOGRAPHY | 2007年 / 21卷 / 12期
关键词：
paracetamol; ibuprofen; diclofenac; HPLC; TLC; spectrophotometry; non-opioid analgesic compounds;
D O I：
10.1002/bmc.885
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and sensitive method for separation and quantitative determination of non-opioid analgesics from pharmaceutical preparations has been developed and validated. Commercial formulations of three non-opioid analgesics, viz. paracetamol, ibuprofen and diclofenac, were chosen for present studies. These were extracted, isolated, purified and recrystallized and were characterized by melting point, lambda(max) and IR. Quantitative determination was carried out using HPLC and TLC supplemented with UV spectrophotometry. Copyright (c) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码：1284 / 1290
页数：7
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