Emission enhancement and application of synthetic green fluorescent protein chromophore analogs

被引：48
|
作者：
Deng, Hongping [1 ]
Zhu, Xinyuan [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
来源：
MATERIALS CHEMISTRY FRONTIERS | 2017年 / 1卷 / 04期
基金：
中国国家自然科学基金;
关键词：
INTRAMOLECULAR PROTON-TRANSFER; ULTRAFAST VIBRATIONAL SPECTROSCOPY; AGGREGATION-INDUCED EMISSION; EXCITED-STATE DYNAMICS; GFP-LIKE CHROMOPHORES; CONFINED CHROMOPHORES; OPTICAL-PROPERTIES; STRUCTURAL BASIS; ENERGY-TRANSFER; DERIVATIVES;
D O I：
10.1039/c6qm00148c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The unique optical properties of genetically encoded green fluorescent protein (GFP) inspire the chemical synthesis, photophysical characterization and application of synthetic GFP chromophore (GFPc) analogs. In this Feature Article, we summarize the recent progress in the fluorescence enhancement and application of synthetic GFPc analogs. In view of fluorescence enhancement, various methods can be classified into physical encapsulation and chemical modification, which can inhibit the chromophores' ultrafast internal conversion. Thus, synthetic GFPc analogs hold great potential as promising candidates in the development of novel sensors or fluorescent probes.
引用
收藏
页码：619 / 629
页数：11
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