Highly brominated metabolites from marine red alga Laurencia similis inhibit protein tyrosine phosphatase 1B

被引：50
作者：
Qin, Jianchun [1 ]
Su, Hua [2 ]
Zhang, Yamei [1 ]
Gao, Jinming [3 ]
Zhu, Lin [1 ]
Wu, Xian [1 ]
Pan, Hongyu [1 ]
Li, Xiang [1 ,4 ]
机构：
[1] Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China
[2] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
[3] NW A&F Univ, Nat Med Chem Res Ctr, Coll Sci, Yangling 712100, Peoples R China
[4] Agr & Agri Food Canada, Saskatoon, SK S7N 0X2, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Brominated metabolites; Laurencia similis; Protein tyrosine phosphatase 1B; ARISTOLANE SESQUITERPENES;
D O I：
10.1016/j.bmcl.2010.08.144
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new highly brominated metabolites, 3',5',6',6-tetrabromo-2,4-dimethyldiphenyl ether (1), 1,2,5-tribromo-3-bromoamino-7-bromomethylnaphthalene (2), 2,5,8-tribromo-3-bromoamino-7-bromomethylnaphthalene (3), 2,5,6-tribromo-3-bromoamino-7-bromomethylnaphthalene (4) and 2',5',6',5, 6-pentabromo-3',4',3,4-tetramethoxybenzo-phenone (5) were isolated from the red alga Laurencia similis. Their structures were elucidated by spectroscopic methods including one-and two-dimensional NMR as well as HREIMS analysis. Compounds 1 and 5 showed strong inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 of 2.97 and 2.66 mu M, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7152 / 7154
页数：3
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