Recent advances in mesoporous silica nanoparticles for antitumor therapy: our contribution

被引:77
作者
Baeza, Alejandro [1 ,2 ]
Manzano, Miguel [1 ,2 ]
Colilla, Montserrat [1 ,2 ]
Vallet-Regi, Maria [1 ,2 ]
机构
[1] Univ Complutense Madrid, Dept Quim Inorgan & Bioinorgan, Fac Farm, Inst Invest Sanitaria,Hosp Octubre I 12 12, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain
[2] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid, Spain
关键词
MESENCHYMAL STEM-CELLS; TARGETED-DELIVERY VEHICLE; DRUG-DELIVERY; DIFFERENT MORPHOLOGIES; CANCER-CHEMOTHERAPY; ANTICANCER DRUG; RELEASE; NANOCARRIERS; BIOCOMPATIBILITY; TUMORS;
D O I
10.1039/c6bm00039h
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Since 2001, when our research group proposed for the first time MCM-41 as a drug release system, the scientific community has demonstrated a growing interest in mesoporous silica nanoparticles (MSNs) for their revolutionary potential in nanomedicine. Among the diverse pathologies that can be treated with MSNs, cancer has received increasing attention. MSNs can be loaded with large amounts of therapeutic cargoes and once intravenously administrated preferentially accumulate in solid tumours via the enhanced permeation and retention (EPR) effect. Herein we report the recent developments achieved by our research group as a pioneer in this field, highlighting: the design of sophisticated MSNs as stimuli-responsive drug delivery systems to release the entrapped cargo upon exposure to a given stimulus while preventing the premature release of highly cytotoxic drugs before reaching the target; transporting non-toxic prodrugs and the enzyme responsible for its conversion into cytotoxic agents into the same MSNs; improving the selectivity and cellular uptake by cancer cells by active targeting of MSNs; increasing the penetration of MSNs within the tumour mass, which is one of the major challenges in the use of NPs to treat solid tumours.
引用
收藏
页码:803 / 813
页数:11
相关论文
共 94 条
  • [1] Nanoparticulate Alternatives for Drug Delivery
    Adair, James H.
    Parette, Mylisa P.
    Altinoglu, Erhan I.
    Kester, Mark
    [J]. ACS NANO, 2010, 4 (09) : 4967 - 4970
  • [2] Gated supramolecular chemistry in hybrid mesoporous silica nanoarchitectures: controlled delivery and molecular transport in response to chemical, physical and biological stimuli
    Alberti, Sebastian
    Soler-Illia, Galo J. A. A.
    Azzaroni, Omar
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (28) : 6050 - 6075
  • [3] Supramolecular mechanisms in the synthesis of mesoporous magnetic nanospheres for hyperthermia
    Arcos, Daniel
    Fal-Miyar, Vanesa
    Ruiz-Hernandez, Eduardo
    Garcia-Hernandez, Mar
    Luisa Ruiz-Gonzalez, M.
    Gonzalez-Calbet, Jose
    Vallet-Regi, Maria
    [J]. JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (01) : 64 - 72
  • [4] Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
    Argyo, Christian
    Weiss, Veronika
    Braeuchle, Christoph
    Bein, Thomas
    [J]. CHEMISTRY OF MATERIALS, 2014, 26 (01) : 435 - 451
  • [5] Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles
    Baek, Seonmi
    Singh, Rajendra K.
    Khanal, Dipesh
    Patel, Kapil D.
    Lee, Eun-Jung
    Leong, Kam W.
    Chrzanowski, Wojciech
    Kim, Hae-Won
    [J]. NANOSCALE, 2015, 7 (34) : 14191 - 14216
  • [6] Thermoseeds for interstitial magnetic hyperthermia: from bioceramics to nanoparticles
    Baeza, A.
    Arcos, D.
    Vallet-Regi, M.
    [J]. JOURNAL OF PHYSICS-CONDENSED MATTER, 2013, 25 (48)
  • [7] Baeza A, 2014, BIO AND BIOINSPIRED, P23, DOI [10.1002/9783527675821.ch02, DOI 10.1002/9783527675821.CH02]
  • [8] Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery
    Baeza, Alejandro
    Colilla, Montserrat
    Vallet-Regi, Maria
    [J]. EXPERT OPINION ON DRUG DELIVERY, 2015, 12 (02) : 319 - 337
  • [9] Hybrid Enzyme-Polymeric Capsules/Mesoporous Silica Nanodevice for In Situ Cytotoxic Agent Generation
    Baeza, Alejandro
    Guisasola, Eduardo
    Torres-Pardo, Almudena
    Gonzalez-Calbet, Jose M.
    Melen, Gustavo J.
    Ramirez, Manuel
    Vallet-Regi, Maria
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (29) : 4625 - 4633
  • [10] The journey of a drug-carrier in the body: An anatomo-physiological perspective
    Bertrand, Nicolas
    Leroux, Jean-Christophe
    [J]. JOURNAL OF CONTROLLED RELEASE, 2012, 161 (02) : 152 - 163