A stable DNA tetraloop and its structural tolerance for modification

被引：5
作者：
Kawakami, J
Yoneyama, M
Miyoshi, D
Sugimoto, N
机构：
[1] Konan Univ, Fac Sci, Dept Chem, Higashinada Ku, Kobe, Hyogo 6588501, Japan
[2] Konan Univ, High Technol Res Ctr, Higashinada Ku, Kobe, Hyogo 6588501, Japan
来源：
CHEMISTRY LETTERS | 2001年 / 03期
关键词：
D O I：
10.1246/cl.2001.258
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Structural features of a stable hairpin DNA with a tetraloop, dAGGC(TTCG)GCCT (CORE), and its six abasic mutants were investigated by the melting behavior of the UV absorption and circular dichroism spectra. The CORE and an abasic mutant at the second position of the loop exhibit considerable thermodynamic stability and have similar structural features suggesting the same folding with an identical base orientation of the two hairpin DNAs except for the second base in the loop.
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页码：258 / 259
页数：2
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