Enantio-, regio-, and chemoselective reduction of aromatic α-diketones by baker's yeast

被引：18

作者：

Mahmoodi, NO ^{[1
]}

Mohammadi, HG ^{[1
]}

机构：

[1] Univ Guilan, Dept Chem, Org Res Lab, Rasht, Iran

来源：

MONATSHEFTE FUR CHEMIE | 2003年 / 134卷 / 09期

关键词：

asymmetric synthesis; chemoselectivity; chiral alpha-hydroxy ketones; alpha-diketone; yeast;

D O I：

10.1007/s00706-003-0042-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantio- and regioselective reduction of several symmetric and nonsymmetrically para-substituted benzil derivatives (21-92%) was achieved by means of Saccharomyces cerevisiae (baker's yeast). After modification of the reaction conditions reduction of nonsymmetric alpha-diketones led chemoselectively to chiral alpha-hydroxy ketones with up to 82% ee.

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收藏

页码：1283 / 1288

页数：6

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