Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications

被引：79

作者：

Chen, Shu ^{[2
,3
]}

Wang, Lijun ^{[1
]}

Duce, Suzanne L. ^{[4
]}

Brown, Stuart ^{[1
]}

Lee, Stephen ^{[2
]}

Melzer, Andreas ^{[1
]}

Cuschieri, Sir Alfred ^{[1
]}

Andre, Pascal ^{[2
]}

机构：

[1] Univ Dundee, Inst Med Sci & Technol, Dundee DD2 1FD, Scotland

[2] Univ St Andrews, Sch Phys & Astron SUPA, St Andrews KY16 9SS, Fife, Scotland

[3] Univ St Andrews, Sch Chem EaSt CHEM, St Andrews KY16 9ST, Fife, Scotland

[4] Univ Dundee, Coll Life Sci, Div Biol Chem & Drug Discovery, Dundee DD1 5EH, Scotland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 42期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

BIOFUNCTIONAL MAGNETIC NANOPARTICLES; SIZE-CONTROLLED FCC; FEPT NANOPARTICLES; MRI CONTRAST; CELLULAR UPTAKE; QUANTUM-DOT; AGENT; STABILITY; MECHANISM; CYTOTOXICITY;

D O I：

10.1021/ja106543j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron-platinum alloy nanoparticles (FePt NPs) are extremely promising candidates for the next generation of contrast agents for magnetic resonance (MR) diagnostic imaging and MR-guided interventions, including hyperthermic ablation of solid cancers. FePt has high Curie temperature, saturation magnetic moment, magneto-crystalline anisotropy, and chemical stability. We describe the synthesis and characterization of a family of biocompatible FePt NPs suitable for biomedical applications, showing and discussing that FePt NPs can exhibit low cytotoxicity. The importance of engineering the interface of strongly magnetic NPs using a coating allowing free aqueous permeation is demonstrated to be an essential parameter in the design of new generations of diagnostic and therapeutic MRI contrast agents. We report effective cell internalization of FePt NPs and demonstrate that they can be used for cellular imaging and in vivo MRI applications. This opens the way for several future applications of FePt NPs, including regenerative medicine and stem cell therapy in addition to enhanced MR diagnostic imaging.

引用

页码：15022 / 15029

页数：8

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